肿瘤微环境在非小细胞肺癌中的临床意义。
Clinical significance of the tumor microenvironment in non-small cell lung cancer.
机构信息
Department of General Thoracic Surgery, Kawasaki Medical School, Kurashiki, Japan.
出版信息
Ann Transl Med. 2013 Jul;1(2):20. doi: 10.3978/j.issn.2305-5839.2013.06.01.
Abstract
Several biomarkers have been reported as predictors of survival and recurrence in non-small cell lung cancer. Recently, several groups have demonstrated that the immune microenvironment of the primary tumors is a prognostic factor. These "immunological biomarkers" in the tumor microenvironment are useful predictors of prognosis as well as promising targets for novel therapeutic approaches. Especially, tumor-infiltrating Treg cells are a powerful immunological biomarker, and possible mechanisms involved in the induction of tumor-infiltrating Treg cells are the expression of Cox-2, IL-12Rβ2 or the lack of IL7R on the tumor cells. These findings may pave the way for individualized immunomodulatory therapies to deplete tumor-infiltrating Treg cells from the tumor microenvironment.
摘要
已有多项生物标志物被报道可预测非小细胞肺癌的生存和复发情况。最近，有几个研究小组已经证实，原发性肿瘤的免疫微环境是一个预后因素。肿瘤微环境中的这些“免疫生物标志物”不仅是预后的有用预测指标，而且也是新型治疗方法的有希望的靶点。特别是肿瘤浸润性 Treg 细胞是一种强大的免疫生物标志物，诱导肿瘤浸润性 Treg 细胞的可能机制是 Cox-2、IL-12Rβ2 的表达或肿瘤细胞上缺乏 IL7R。这些发现可能为个体化免疫调节治疗铺平道路，以从肿瘤微环境中耗尽肿瘤浸润性 Treg 细胞。
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