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IL7R与肺腺癌肿瘤微环境中的免疫细胞浸润相关。

IL7R Is Correlated With Immune Cell Infiltration in the Tumor Microenvironment of Lung Adenocarcinoma.

作者信息

Wang Xin, Chang Shujian, Wang Teng, Wu Ruirong, Huang Zebo, Sun Junjie, Liu Jingjing, Yu Yan, Mao Yong

机构信息

Department of Medical Oncology, Affiliated Hospital of Jiangnan University, Wuxi, China.

Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.

出版信息

Front Pharmacol. 2022 Feb 21;13:857289. doi: 10.3389/fphar.2022.857289. eCollection 2022.

DOI:10.3389/fphar.2022.857289
PMID:35264973
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8899515/
Abstract

Tumor microenvironment plays an important role in the development, progression, and prognosis of lung adenocarcinoma. Exploring new biomarkers based on the immune microenvironment of lung adenocarcinoma can effectively predict the prognosis and provide effective clinical treatment. In this study, we used the ESTIMATE algorithm to score the immune and stromal components in lung adenocarcinoma data downloaded from the TCGA database. The result showed that the immune/stromal score was associated with clinical features and prognosis of lung adenocarcinoma patients. Interleukin-7 receptor (IL7R) is an important prognostic biomarker identified by intersection analysis of protein-protein interaction networks and Cox regression survival analysis. According to TCGA and Oncomine database analysis, IL7R expression in adenocarcinoma tissues was significantly lower than that in normal lung tissues and was further verified in clinical tissue samples. Survival analysis showed IL7R was an independent prognostic factor of lung adenocarcinoma. IL7R expression was positively correlated with the overall survival and progression-free survival of lung adenocarcinoma patients and negatively correlated with tumor size. Our results suggest that IL7R inhibits tumor growth by regulating the proportion of immune infiltrating cells in the tumor immune microenvironment. IL7R could be a beneficial prognostic marker in patients with lung adenocarcinoma and has great potential in immune therapy.

摘要

肿瘤微环境在肺腺癌的发生、发展及预后中起着重要作用。基于肺腺癌免疫微环境探索新的生物标志物能够有效预测预后并提供有效的临床治疗方案。在本研究中，我们使用ESTIMATE算法对从TCGA数据库下载的肺腺癌数据中的免疫和基质成分进行评分。结果显示，免疫/基质评分与肺腺癌患者的临床特征和预后相关。白细胞介素-7受体（IL7R）是通过蛋白质-蛋白质相互作用网络和Cox回归生存分析的交叉分析确定的重要预后生物标志物。根据TCGA和Oncomine数据库分析，腺癌组织中IL7R表达明显低于正常肺组织，并在临床组织样本中得到进一步验证。生存分析表明，IL7R是肺腺癌的独立预后因素。IL7R表达与肺腺癌患者的总生存期和无进展生存期呈正相关，与肿瘤大小呈负相关。我们的结果表明，IL7R通过调节肿瘤免疫微环境中免疫浸润细胞的比例来抑制肿瘤生长。IL7R可能是肺腺癌患者有益的预后标志物，在免疫治疗中具有巨大潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ffa/8899515/2d501bd43370/fphar-13-857289-g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ffa/8899515/2d501bd43370/fphar-13-857289-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ffa/8899515/e26f37e48121/fphar-13-857289-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ffa/8899515/542910f92156/fphar-13-857289-g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ffa/8899515/2d501bd43370/fphar-13-857289-g007.jpg

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本文引用的文献

1
Cancer Statistics, 2021.癌症统计数据，2021.
CA Cancer J Clin. 2021 Jan;71(1):7-33. doi: 10.3322/caac.21654. Epub 2021 Jan 12.
2
B cells are associated with survival and immunotherapy response in sarcoma.B 细胞与肉瘤的生存和免疫治疗反应有关。
Nature. 2020 Jan;577(7791):556-560. doi: 10.1038/s41586-019-1906-8. Epub 2020 Jan 15.
3
B cells and tertiary lymphoid structures promote immunotherapy response.B 细胞和三级淋巴结构促进免疫治疗反应。
构建用于肝细胞癌预后的肿瘤免疫微环境相关风险评分模型。
Int J Immunopathol Pharmacol. 2025 Jan-Dec;39:3946320251333975. doi: 10.1177/03946320251333975. Epub 2025 Apr 23.
4
Causal association of breast cancer with immune cells: new evidence from bi-directional Mendelian randomization using GWAS summary statistics.乳腺癌与免疫细胞的因果关联：基于全基因组关联研究（GWAS）汇总统计数据的双向孟德尔随机化新证据
BMC Cancer. 2025 Apr 3;25(1):609. doi: 10.1186/s12885-025-13875-w.
5
Construction of enhanced MRI-based radiomics models using machine learning algorithms for non-invasive prediction of IL7R expression in high-grade gliomas and its prognostic value in clinical practice.利用机器学习算法构建基于增强磁共振成像的影像组学模型，用于无创预测高级别胶质瘤中IL7R的表达及其在临床实践中的预后价值。
J Transl Med. 2025 Mar 31;23(1):383. doi: 10.1186/s12967-025-06402-9.
6
Sequential transcriptome profiling: comparative analysis of normal and canine lymphoma preceding detailed T-cell and B-cell subtype comparison.连续转录组分析：在详细的T细胞和B细胞亚型比较之前对正常犬和犬淋巴瘤进行的比较分析。
Front Vet Sci. 2025 Jan 22;11:1473421. doi: 10.3389/fvets.2024.1473421. eCollection 2024.
7
Notch3 deletion regulates HIV-1 gene expression and systemic inflammation to ameliorate chronic kidney disease.Notch3基因缺失可调节HIV-1基因表达和全身炎症反应，从而改善慢性肾脏病。
Dis Model Mech. 2025 Feb 1;18(2). doi: 10.1242/dmm.052056. Epub 2025 Feb 25.
8
Identification and validation of a novel innate lymphoid cell-based signature to predict prognosis and immune response in liver cancer by integrated single-cell RNA analysis and bulk RNA sequencing.通过整合单细胞RNA分析和批量RNA测序鉴定并验证一种基于新型固有淋巴细胞的特征，以预测肝癌的预后和免疫反应。
Transl Cancer Res. 2024 Oct 31;13(10):5395-5416. doi: 10.21037/tcr-24-725. Epub 2024 Oct 28.
9
scImmOmics: a manually curated resource of single-cell multi-omics immune data.scImmOmics：一个人工整理的单细胞多组学免疫数据资源。
Nucleic Acids Res. 2025 Jan 6;53(D1):D1162-D1172. doi: 10.1093/nar/gkae985.
10
An IL-7 fusion protein targeting EDA fibronectin upregulates TCF1 on CD8+ T-cells, preferentially accumulates to neoplastic lesions, and boosts PD-1 blockade.一种靶向 EDA 纤连蛋白的 IL-7 融合蛋白可上调 CD8+ T 细胞中的 TCF1，优先积累至肿瘤病变部位，并增强 PD-1 阻断作用。
J Immunother Cancer. 2024 Aug 13;12(8):e008504. doi: 10.1136/jitc-2023-008504.
Nature. 2020 Jan;577(7791):549-555. doi: 10.1038/s41586-019-1922-8. Epub 2020 Jan 15.
4
Tertiary lymphoid structures improve immunotherapy and survival in melanoma.三级淋巴结构可改善黑色素瘤的免疫治疗和生存率。
Nature. 2020 Jan;577(7791):561-565. doi: 10.1038/s41586-019-1914-8. Epub 2020 Jan 15.
5
The lymphoid-associated interleukin 7 receptor (IL7R) regulates tissue-resident macrophage development.淋巴相关白细胞介素 7 受体（IL7R）调节组织驻留巨噬细胞的发育。
Development. 2019 Jul 22;146(14):dev176180. doi: 10.1242/dev.176180.
6
Tertiary lymphoid structures in the era of cancer immunotherapy.癌症免疫治疗时代的三级淋巴结构。
Nat Rev Cancer. 2019 Jun;19(6):307-325. doi: 10.1038/s41568-019-0144-6.
7
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.全球癌症统计数据 2018：GLOBOCAN 对全球 185 个国家/地区 36 种癌症的发病率和死亡率的估计。
CA Cancer J Clin. 2018 Nov;68(6):394-424. doi: 10.3322/caac.21492. Epub 2018 Sep 12.
8
A Structured Tumor-Immune Microenvironment in Triple Negative Breast Cancer Revealed by Multiplexed Ion Beam Imaging.多重离子束成像揭示三阴性乳腺癌中的结构化肿瘤免疫微环境。
Cell. 2018 Sep 6;174(6):1373-1387.e19. doi: 10.1016/j.cell.2018.08.039.
9
Phenotype molding of stromal cells in the lung tumor microenvironment.肺肿瘤微环境中基质细胞的表型塑造。
Nat Med. 2018 Aug;24(8):1277-1289. doi: 10.1038/s41591-018-0096-5. Epub 2018 Jul 9.
10
Sequencing cells of the immune TME.对免疫肿瘤微环境中的细胞进行测序。
Nat Rev Clin Oncol. 2018 Sep;15(9):531. doi: 10.1038/s41571-018-0069-0.