未感染艾滋病毒的南非青少年中多重人乳头瘤病毒并发感染率高。
High Rate of Multiple Concurrent Human Papillomavirus Infections among HIV-Uninfected South African Adolescents.
作者信息
Adler David, Laher Fatima, Wallace Melissa, Grzesik Katherine, Jaspan Heather, Bekker Linda-Gail, Gray Glenda, Valley-Omar Ziyaad, Allan Bruce, Williamson Anna-Lise
机构信息
Department of Emergency Medicine, University of Rochester, Rochester, NY, USA.
Perinatal HIV Research Unit, University of the Witwatersrand, Chris Hani Baragwanath Hospital, Diepkloof, South Africa.
出版信息
J Immunol Tech Infect Dis. 2013;2(1):1000106.
BACKGROUND
The epidemiology and impact of multiple concurrent Human papillomavirus (HPV) infections on the natural history of cervical disease is uncertain, but could have significant implications for cervical cancer prevention and HPV vaccination strategies.
METHODS
A cross-sectional prevalence study was conducted to determine the overall prevalence of HPV and the rate of multiple concurrent HPV infections, in a cohort of sexually active HIV-uninfected South African adolescents. HPV genotyping was performed using the polymerase chain reaction.
RESULTS
Overall prevalence of HPV was 64.1%. Multiple concurrent HPV infections were found in 43.6% of participants and 68% of HPV-infected participants. Non-vaccine high-risk HPV (HR-HPV) genotypes were found much more often than vaccine types (HPV16 and HPV18).
CONCLUSIONS
Our cohort of young South African females was found to have a high overall prevalence of HPV and multiple concurrent HPV infections. Most HR-HPV infections found were genotypes other than HPV16 or HPV18.
背景
多种人乳头瘤病毒（HPV）同时感染对宫颈疾病自然史的流行病学及影响尚不确定，但可能对宫颈癌预防和HPV疫苗接种策略有重大影响。
方法
开展一项横断面患病率研究，以确定一群性活跃、未感染艾滋病毒的南非青少年中HPV的总体患病率及多种HPV同时感染率。采用聚合酶链反应进行HPV基因分型。
结果
HPV总体患病率为64.1%。43.6%的参与者以及68%的HPV感染参与者存在多种HPV同时感染情况。非疫苗高危HPV（HR-HPV）基因型的发现频率远高于疫苗型（HPV16和HPV18）。
结论
我们发现南非年轻女性群体中HPV总体患病率及多种HPV同时感染率较高。所发现的大多数HR-HPV感染为HPV16或HPV18以外的基因型。
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