Yoldemir T, Yavuz D G
*Department of Obstetrics and Gynecology, Marmara University , Istanbul , Turkey.
Climacteric. 2015 Jun;18(3):405-10. doi: 10.3109/13697137.2014.975196. Epub 2014 Dec 11.
To determine the association of serum paraoxonase concentration with serum lipid levels and bone mineral density in early postmenopausal Turkish women.
One hundred healthy postmenopausal women were included in a cross-sectional study in a University hospital clinic. Blood was drawn from women who had bone mineral density (BMD) measurements during routine visits. BMD of the lumbar vertebrae was measured by dual-energy X-ray absorptiometry. The serum paraoxonase concentration and serum lipid levels were measured. Women were divided into two groups: those with normal lumbar vertebrae BMD and those with osteopenic lumbar vertebrae. Serum paraoxonase concentration was compared between the groups. The correlation between serum paraoxonase concentration and bone mass parameters was performed using Pearson's test.
The paraoxonase concentration in the osteopenic group was significantly lower than in the group with normal lumbar vertebrae BMD. The paraoxonase concentration was moderately correlated with total cholesterol, low density lipoprotein cholesterol and triglyceride levels among early postmenopausal Turkish women.
Early postmenopausal women with osteopenic lumbar vertebrae have significantly lower paraoxonase concentration than those with normal lumbar vertebrae BMD. Further studies are needed to clarify the associations between the osteoporosis risk factors and paraoxonase concentration during late postmenopausal years.
确定绝经后早期土耳其女性血清对氧磷酶浓度与血脂水平及骨密度之间的关联。
在一家大学医院诊所对100名健康绝经后女性进行横断面研究。从在常规就诊期间进行骨密度（BMD）测量的女性中采集血液。采用双能X线吸收法测量腰椎骨密度。测量血清对氧磷酶浓度和血脂水平。女性被分为两组：腰椎骨密度正常组和腰椎骨量减少组。比较两组之间的血清对氧磷酶浓度。使用Pearson检验进行血清对氧磷酶浓度与骨量参数之间的相关性分析。
骨量减少组的对氧磷酶浓度显著低于腰椎骨密度正常组。在绝经后早期土耳其女性中，对氧磷酶浓度与总胆固醇、低密度脂蛋白胆固醇和甘油三酯水平呈中度相关。
腰椎骨量减少的绝经后早期女性的对氧磷酶浓度显著低于腰椎骨密度正常的女性。需要进一步研究以阐明绝经后期骨质疏松风险因素与对氧磷酶浓度之间的关联。
