Mendlovic F, Tarrab-Hazdai R, Puri J, Arnon R
Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel.
Parasite Immunol. 1989 Nov;11(6):667-82. doi: 10.1111/j.1365-3024.1989.tb00928.x.
The influence of the I region of the major histocompatibility complex (MHC) on T-dependent immune responses against a purified schistosome antigen (9B antigen) was investigated. H-2 congenic mice expressing both I-A and I-E antigens (I-E+) showed a higher in-vitro proliferation to 9B antigen as compared to the recombinant strains expressing only I-A (I-E-). These two strains of mice differed both qualitatively and quantitatively in the humoral responses elicited by the purified antigen. Furthermore, in-vivo protection experiments showed that mice which do not express I-E molecules can be partially protected against the disease by prior immunization with the 9B antigen in contrast to their I-E expressing counterparts. The possible role of the I-E molecule in the immune responses elicited during Schistosoma mansoni infection is discussed.
研究了主要组织相容性复合体（MHC）的I区对针对纯化血吸虫抗原（9B抗原）的T细胞依赖性免疫反应的影响。表达I-A和I-E抗原（I-E+）的H-2同基因小鼠与仅表达I-A（I-E-）的重组品系相比，对9B抗原的体外增殖更高。这两种品系的小鼠在纯化抗原引发的体液反应中，在质量和数量上均存在差异。此外，体内保护实验表明，不表达I-E分子的小鼠与表达I-E分子的对应小鼠相比，通过预先用9B抗原免疫可部分抵抗该疾病。本文讨论了I-E分子在曼氏血吸虫感染期间引发的免疫反应中的可能作用。
