一种针对曼氏血吸虫的基于保护性肽的疫苗的合成与表征
Synthesis and characterization of a protective peptide-based vaccine against Schistosoma mansoni.
作者信息
Tarrab-Hazdai R, Schechtman D, Arnon R
机构信息
Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel.
出版信息
Infect Immun. 1998 Sep;66(9):4526-30. doi: 10.1128/IAI.66.9.4526-4530.1998.
Abstract
Two synthetic peptides, corresponding to the N-terminal sequence of the 45-kDa subunit of the protective 9B antigen of Schistosoma mansoni and differing in only one amino acid residue, were synthesized. These peptides were recognized by the protective monoclonal antibody 152-66-9B, as well as by sera of mice and humans infected with schistosomiasis. The peptides were coupled to a protein carrier and used for immunization. One of the peptides, 9B-peptide1, induced in mice significant protection against challenge infection, manifested in a 40 to 50% reduction in worm burden.
摘要
合成了两种对应于曼氏血吸虫保护性9B抗原45 kDa亚基N端序列且仅一个氨基酸残基不同的合成肽。这些肽能被保护性单克隆抗体152 - 66 - 9B以及感染血吸虫病的小鼠和人类血清所识别。将这些肽与蛋白质载体偶联并用于免疫。其中一种肽，9B - 肽1，在小鼠中诱导出对攻击感染的显著保护作用，表现为虫体负荷降低40%至50%。
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