Department of Chemical Engineering, Monash University, Clayton 3800, Victoria, Australia.
Nanoscale. 2014 Nov 6;6(23):14388-93. doi: 10.1039/c4nr04400b.
A new near-infrared light-controlled drug delivery system based on caged gold nanorods (CGNRs) is demonstrated. The loading and release process of drug payloads into/from CGNR nanocarriers were systematically investigated. The drug-loaded CGNR constructs could enable combined chemotherapy and photo-thermal effects in killing tumor cells upon light irradiation, therefore, enhance the killing efficiency. In conjunction with visibility under quenching-free dark-field imaging, CGNRs may serve as multifunctional theranostic reagents towards cancer diagnostics and therapeutics.
研究了基于笼状金纳米棒（CGNR）的新型近红外光控药物输送系统。系统研究了药物有效负载进入/离开 CGNR 纳米载体的加载和释放过程。负载药物的 CGNR 构建体可以在光照射下实现联合化学疗法和光热效应，从而提高杀伤肿瘤细胞的效率。结合在无猝灭暗场成像下的可见性，CGNR 可作为癌症诊断和治疗的多功能治疗试剂。
