一种用于高效递送不稳定蛋白质的无溶剂热海绵纳米颗粒平台。
A solvent-free thermosponge nanoparticle platform for efficient delivery of labile proteins.
作者信息
Choi Won Il, Kamaly Nazila, Riol-Blanco Lorena, Lee In-Hyun, Wu Jun, Swami Archana, Vilos Cristian, Yameen Basit, Yu Mikyung, Shi Jinjun, Tabas Ira, von Andrian Ulrich H, Jon Sangyong, Farokhzad Omid C
机构信息
Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women's Hospital and ‡Department of Microbiology and Immunobiology, Division of Immunology, Harvard Medical School , Boston, Massachusetts 02115, United States.
出版信息
Nano Lett. 2014 Nov 12;14(11):6449-55. doi: 10.1021/nl502994y. Epub 2014 Oct 21.
Abstract
Protein therapeutics have gained attention recently for treatment of a myriad of human diseases due to their high potency and unique mechanisms of action. We present the development of a novel polymeric thermosponge nanoparticle for efficient delivery of labile proteins using a solvent-free polymer thermo-expansion mechanism with clinical potential, capable of effectively delivering a range of therapeutic proteins in a sustained manner with no loss of bioactivity, with improved biological half-lives and efficacy in vivo.
摘要
蛋白质疗法因其高效性和独特的作用机制，近年来在治疗多种人类疾病方面受到关注。我们展示了一种新型聚合物热海绵纳米颗粒的研发，该颗粒利用具有临床潜力的无溶剂聚合物热膨胀机制来有效递送不稳定蛋白质，能够持续有效地递送一系列治疗性蛋白质，且生物活性无损失，同时在体内具有更长的生物半衰期和更高的疗效。
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