亚麻籽粉对长期接受雄激素刺激的大鼠血脂水平的影响。

Effects of flaxseed flour on the lipid profile of rats submitted to prolonged androgen stimuli.

作者信息

Ribeiro Ilma Cely de Amorim, da Costa Carlos Alberto Soares, Alves Pereira Vivian, Teles Boaventura Gilson, Alves Chagas Mauricio

机构信息

Department of Morphology, Laboratory of Cellular and Extracellular Biomorphology Biomedic Institute, Federal Fluminense University. Brasil..

Department of Nutrition and Dietetics, Experimental Nutrition Laboratory, College of Nutrition, Federal Fluminense University, Rio de Janeiro, Brazil..

出版信息

Nutr Hosp. 2014 Oct 1;30(4):825-30. doi: 10.3305/nh.2014.30.4.7301.

DOI:10.3305/nh.2014.30.4.7301

PMID:25335669

Abstract

BACKGROUND

The chronic use of steroid hormones can lead to alterations in the lipid profile such as an increase in LDL and decrease in HDL levels . The effect of flaxseed on lipid profiles has been widely investigated.

AIM

Evaluate the lipid profile of adult male Wistar rats fed with flax based meals and submitted to androgenic hyperstimulation.

MATERIAL AND METHODS

Forty Wistar rats were divided into 4 groups of 10 animals: the Control group (CG); Flax group (FG) fed a flaxseed flour-based meal; Induced group (IG); and the Induced group (IGF) that was fed a flaxseed flour-based meal. The induction was done by using silicone pellets filled with testosterone propionate (1mg), sealed with a surgical adhesive and substituted every 4 weeks.

RESULTS

Triglycerides (FG: 71.16 ± 21.95; IG: 99.16 ± 26.00 and IGF: 86.33 ± 27.16 mg/dL) and HDL-cholesterol (FG: 23.05 ± 1.67; IG: 29.06 ± 7.24 and IGF: 26.06 ± 3.56 mg/dL) were significantly lower in the experimental groups. The FG and IGF (41.16 ± 3.97 and 49.66 ± 11.25 mg/dL, respectively) showed significantly lower levels of cholesterol than the other groups(CG: 78,85 ± 11.58 and IG: 70,83 ± 14.85 mg/dL). Regarding LDL levels, the IG showed significantly higher concentrations (21,93 ± 8,84 mg/dL) than the others groups (CG: 7,81 ± 5,37; FG: 3,88 ± 1,32 and IGF: 6,66 ± 7,24 mg/dL).

CONCLUSIONS

The flaxseed has a relevant effect on the lipid profile of animals submitted to androgenic hyperstimulation.

摘要

背景

长期使用类固醇激素会导致血脂谱改变，如低密度脂蛋白升高和高密度脂蛋白水平降低。亚麻籽对血脂谱的影响已得到广泛研究。

目的

评估喂食亚麻基膳食并接受雄激素超刺激的成年雄性Wistar大鼠的血脂谱。

材料与方法

40只Wistar大鼠分为4组，每组10只动物：对照组（CG）；喂食亚麻籽粉基膳食的亚麻组（FG）；诱导组（IG）；以及喂食亚麻籽粉基膳食的诱导组（IGF）。诱导通过使用填充丙酸睾酮（1mg）的硅胶丸进行，用手术粘合剂密封，每4周更换一次。

结果

实验组的甘油三酯（FG：71.16±21.95；IG：99.16±26.00和IGF：86.33±27.16mg/dL）和高密度脂蛋白胆固醇（FG：23.05±1.67；IG：29.06±7.24和IGF：26.06±3.56mg/dL）显著降低。FG和IGF（分别为41.16±3.97和49.66±11.25mg/dL）的胆固醇水平显著低于其他组（CG：78.85±11.58和IG：70.83±14.85mg/dL）。关于低密度脂蛋白水平，IG组的浓度（21.93±8.84mg/dL）显著高于其他组（CG：7.81±5.37；FG：3.88±1.32和IGF：6.66±7.24mg/dL）。