Karim Q Abdool, Baxter C, Karim S Abdool
CAPRISA-Centre for the AIDS Programme of Research in South Africa, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa; Department of Epidemiology, Columbia University, New York, NY, USA.
BJOG. 2014 Oct;121 Suppl 5(0 5):53-61. doi: 10.1111/1471-0528.12843.
There is an urgent need for technologies to prevent sexual acquisition of HIV infection in young women in sub-Saharan Africa. After two decades of 11 pivotal trials of seven products, anti-retroviral-based topical microbicides are showing promise. Building on the CAPRISA 004 trial findings, several trials of new anti-viral agents, novel delivery mechanisms and combination/multipurpose products that address challenges of adherence and meet the sexual and reproductive health needs of men and women, including preventing HIV infection, are underway.
撒哈拉以南非洲地区迫切需要能够防止年轻女性通过性行为感染艾滋病毒的技术。在对7种产品进行了20年的11项关键试验后，基于抗逆转录病毒的局部杀菌剂显示出了前景。基于CAPRISA 004试验的结果，一些针对新抗病毒药物、新型给药机制以及组合/多功能产品的试验正在进行，这些产品旨在应对依从性挑战，并满足男性和女性的性健康和生殖健康需求，包括预防艾滋病毒感染。
