Mngadi Kathryn Therese, Maarschalk Silvia, Grobler Anneke C, Mansoor Leila E, Frohlich Janet A, Madlala Bernadette, Ngcobo Nelisiwe, Abdool Karim Salim S, Abdool Karim Quarraisha
Centre for the AIDS Program of Research in South Africa, Doris, Duke Medical Research Institute, University of KwaZulu-Natal, Nelson R Mandela School of Medicine, 2nd Floor, Private Bag X7, Congella, 4013, South Africa,
AIDS Behav. 2014 May;18(5):849-54. doi: 10.1007/s10461-014-0696-0.
Young women in sub-Saharan Africa are disproportionately affected by HIV, making the development of women initiated and controlled methods of prevention, including microbicides, a priority. Adherence is pivotal to microbicide efficacy and partner related factors are known to impact adherence. An analysis of disclosure of gel use to sexual partners and adherence in CAPRISA 004 women was conducted to better understand this relationship. Partner disclosure was significantly associated with a modest 4.2 % increased adherence (71.0 vs. 66.8 %, p = 0.03). Most women rated the experience of disclosure as positive, despite 6.7 % of partners expressing a negative reaction.Participants who disclosed were more likely to reside with their regular partner (14.4 vs. 8.4 %; p = 0.01) and reported consistent condom use at baseline (32.9 vs. 20.9 %; p < 0.01). Partner disclosure needs to be better understood as a potential facilitator or barrier to microbicide adherence.
撒哈拉以南非洲地区的年轻女性受艾滋病毒影响的比例过高，因此开发由女性发起并控制的预防方法，包括杀菌剂，成为当务之急。坚持使用对于杀菌剂的疗效至关重要，而且已知伴侣相关因素会影响坚持使用情况。为了更好地理解这种关系，对CAPRISA 004研究中的女性向性伴侣披露凝胶使用情况及坚持使用情况进行了分析。向伴侣披露凝胶使用情况与坚持使用适度增加4.2%显著相关（71.0%对66.8%，p = 0.03）。尽管6.7%的伴侣有负面反应，但大多数女性认为披露经历是积极的。披露凝胶使用情况的参与者更有可能与固定伴侣同住（14.4%对8.4%；p = 0.01），并且在基线时报告始终坚持使用避孕套（32.9%对20.9%；p < 0.01）。需要更好地理解向伴侣披露凝胶使用情况这一因素，因为它可能是促进或阻碍坚持使用杀菌剂的因素。
