Central and peripheral effects of the peptide ANF on renal function and blood pressure in hypertensive rats.

1. The present study assesses renal and blood pressure effects of systemically and intracerebroventricularly (I.C.V.) administered atrial natriuretic factor (ANF) in anaesthetized New Zealand genetically hypertensive (NZGH) rats and their normotensive substrain (NZN). 2. Plasma ANF concentration was significantly raised in NZGH compared with NZN animals. Intravenous ANF administration increased circulating ANF concentration to similar levels in NZGH and NZN rats. Plasma aldosterone concentrations were initially similar in normotensive and hypertensive animals and were reduced markedly by I.V. ANF administration in both groups. 3. Peripheral administration of ANF produced a significant and sustained hypotension during the period of the hormone administration in NZGH animals, while arterial mean blood pressure (MBP) was not altered significantly in NZN rats. Central infusion of ANF produced no change in MBP in either NZGH or NZN animals. There was no detectable change in heart rate during central or peripheral administration of the hormone in either group. 4. By comparison with animals maintained on hormone-free infusate, urine flow changed little over the 80 min period of I.V. ANF infusion in NZGH rats but was markedly increased in NZN animals. Urinary sodium excretion was elevated during ANF infusion in both NZGH and NZN animals. Central infusion of ANF produced a diuresis in NZN rats but a slight reduction in urine flow in NZGH animals, while sodium excretion was not affected in either group. 5. It appears from the present study that central and peripheral ANF effects on renal function and blood pressure differ in hypertensive and normotensive animals. These differences may in part reflect adjustments to long-term elevation in plasma ANF in hypertension and in part are possibly associated with disturbances in related endocrine mechanisms.