Rim Tyler Hyungtaek, Lee Christopher Seungkyu, Kim Kangyoon, Kim Sung Soo
Department of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Korea.
Department of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Korea Yonsei Healthcare Big Data-Based Knowledge Integration System Research Center and Institute of Convergence Science, Yonsei University College of Medicine, Seoul, Korea.
Br J Ophthalmol. 2015 Apr;99(4):493-9. doi: 10.1136/bjophthalmol-2014-305525. Epub 2014 Oct 21.
To evaluate changes in choroidal thickness before and after steep Trendelenburg position (STP, 40° head-down) using automated segmentation software to analyse swept-source optical coherence tomography (SS-OCT) data.
The eyes of 20 healthy volunteers underwent a three-dimensional wide scanning protocol with SS-OCT (Topcon, Tokyo, Japan) at baseline, immediately after STP was initiated, and 5, 10 and 15 min after STP; blood pressure and heart rate were measured concurrently. The predictive mean difference was calculated using a generalised linear mixed model that adjusted for potential confounders.
Mean choroidal thickness significantly and transiently increased immediately (268.18±9.24 μm, p<0.01) and 5 min (264.25±9.30 μm, p=0.03) after STP, relative to baseline (256.51±9.20 μm). However, choroidal thickness decreased by 10 min (262.51±9.34 μm, p=0.15) and 15 min (261.38±9.40 μm, p=0.37) after STP. Mean arterial pressure also transiently increased from baseline (78.2±1.2 mm Hg) immediately after STP (79.9±1.1 mm Hg, p=0.01), but normalised by 5 min after STP (p>0.05 for all comparisons ≥5 min).
Choroidal thickness significantly but transiently increases after adopting STP, as evaluated by automated layer segmentation analysis of SS-OCT data.
使用自动分割软件分析扫频源光学相干断层扫描（SS-OCT）数据，以评估在极度头低脚高位（STP，头向下40°）前后脉络膜厚度的变化。
20名健康志愿者的眼睛在基线、开始STP后即刻、STP开始后5、10和15分钟接受了SS-OCT（日本东京拓普康公司）的三维宽扫描方案；同时测量血压和心率。使用调整了潜在混杂因素的广义线性混合模型计算预测平均差异。
相对于基线（256.51±9.20μm），脉络膜厚度在STP后即刻（268.18±9.24μm，p<0.01）和5分钟（264.25±9.30μm，p=0.03）显著且短暂增加。然而，在STP后10分钟（262.51±9.34μm，p=0.15）和15分钟（261.38±9.40μm，p=0.37）脉络膜厚度下降。平均动脉压也在STP后即刻从基线（78.2±1.2mmHg）短暂升高（79.9±1.1mmHg，p=0.01），但在STP后5分钟恢复正常（所有≥5分钟的比较p>0.05）。
通过对SS-OCT数据的自动分层分割分析评估，采用STP后脉络膜厚度显著但短暂增加。
