Clemens R, Bock H L, Enders B, Reiner G
Behringwerke AG, Abteilung Pharmakologie/Toxikologie, Marburg, Federal Republic of Germany.
Parasitol Res. 1989;76(1):36-8. doi: 10.1007/BF00931069.
The effect of AT III substitution on survival time was studied in P. vinkei infected mice. One hundred mice were infected, randomly selected and allocated to two groups of 40 animals each on day 13 after infection. One group was placebo treated, the other group received 3 IU AT III daily on days 13 to 19. Comparison of the survival time in the log rank test showed a prolongation of the median survival time (5 versus 9 days, P less than 0.01). It is concluded that AT III might be beneficial in the treatment of severe malaria cases.
在感染文氏疟原虫的小鼠中研究了抗凝血酶III（AT III）替代治疗对生存时间的影响。100只小鼠被感染，在感染后第13天随机选取并分为两组，每组40只动物。一组接受安慰剂治疗，另一组在第13至19天每天接受3国际单位的AT III。对数秩检验中生存时间的比较显示，中位生存时间延长（5天对9天，P<0.01）。得出结论，AT III可能对重症疟疾病例的治疗有益。
