Horstmann R D, Dietrich M
Blut. 1985 Nov;51(5):329-35. doi: 10.1007/BF00320043.
Fibrin(ogen) degradation products, platelet counts, antithrombin III, and the components of the Factor VIII complex were studied in a total of 80 patients with Plasmodium falciparum, Plasmodium vivax or Plasmodium ovale infections. The haemostatic findings were correlated to the numbers of parasitized erythrocytes and to each other. The results indicate that haemostatic changes in malaria correlate with the degree of parasitaemia. Evidence for moderate hyperfibrinolysis was found in patients with high P. falciparum parasitaemias only. Thrombocytopenia closely corresponded to parasitaemia and to von Willebrand factor levels, but appeared not to be linked to a consumption of coagulation factors. It was concluded that thrombocytopenia in malaria is not indicative of disseminated intravascular coagulation (DIC) but may relate to endothelial damage.
对80例感染恶性疟原虫、间日疟原虫或卵形疟原虫的患者进行了纤维蛋白（原）降解产物、血小板计数、抗凝血酶III以及因子VIII复合物各成分的研究。止血检查结果与寄生红细胞数量以及彼此之间进行了相关性分析。结果表明，疟疾中的止血变化与寄生虫血症程度相关。仅在恶性疟原虫寄生虫血症高的患者中发现了中度纤维蛋白溶解的证据。血小板减少症与寄生虫血症和血管性血友病因子水平密切相关，但似乎与凝血因子的消耗无关。得出的结论是，疟疾中的血小板减少症并非弥散性血管内凝血（DIC）的指征，而可能与内皮损伤有关。
