Department of Thoracic Surgery, Zhejiang Cancer Hospital, Hangzhou, People's Republic of China.
Department of Operating Theater, Zhejiang Cancer Hospital, Hangzhou, People's Republic of China.
Onco Targets Ther. 2014 Sep 30;7:1811-5. doi: 10.2147/OTT.S68084. eCollection 2014.
The prognostic value of inflammation indexes in esophageal cancer has not been established. Recent studies have shown that the advanced lung cancer inflammation index (ALI) is a useful predictive factor. The purpose of the current study was to determine whether the ALI is useful for predicting long-term survival in patients with esophageal squamous cell carcinoma (ESCC).
A total of 293 patients who had undergone esophagectomy for ESCC were included. The ALI was calculated as body mass index × serum albumin/neutrophil-to-lymphocyte ratio. Then, patients were divided into two groups: ALI ≥18 and ALI <18. The Kaplan-Meier method was used to calculate the cancer-specific survival (CSS), and the difference was assessed by the log-rank test. Univariate and multivariate analyses were performed to evaluate the prognostic factors.
In our study, there were 120 patients with ALI <18 and 173 patients with ALI ≥18. ALI was significantly higher in patients with large tumors (P=0.028), poor differentiation (P=0.010), deep invasion (P=0.009), and nodal metastasis (P=0.004). The 5-year CSS was 34.5% in our study. Patients with ALI <18 had a significantly poorer 5-year CSS compared to ALI ≥18 (21.7% versus 43.4%, P<0.001). On multivariate analysis, we showed that the ALI was a significant predictive factor of CSS (P=0.024).
The ALI is still a useful predictive factor for long-term CSS in patients with ESCC. However, the prognostic value of the ALI is yet to be formally tested within randomized trials.
炎症指标在食管癌中的预后价值尚未确定。最近的研究表明，晚期肺癌炎症指数（ALI）是一个有用的预测因素。本研究旨在确定 ALI 是否可用于预测食管鳞状细胞癌（ESCC）患者的长期生存。
共纳入 293 例接受 ESCC 根治性切除术的患者。ALI 计算方法为体重指数×血清白蛋白/中性粒细胞与淋巴细胞比值。然后，患者被分为两组：ALI≥18 和 ALI<18。采用 Kaplan-Meier 法计算癌症特异性生存率（CSS），并采用对数秩检验评估差异。采用单因素和多因素分析评估预后因素。
在本研究中，有 120 例患者的 ALI<18，173 例患者的 ALI≥18。肿瘤较大（P=0.028）、分化较差（P=0.010）、浸润较深（P=0.009）和淋巴结转移（P=0.004）的患者 ALI 明显较高。本研究的 5 年 CSS 为 34.5%。与 ALI≥18 相比，ALI<18 的患者 5 年 CSS 显著较差（21.7%比 43.4%，P<0.001）。多因素分析显示，ALI 是 CSS 的显著预测因素（P=0.024）。
ALI 仍然是 ESCC 患者长期 CSS 的有用预测因素。然而，ALI 的预后价值仍有待在随机试验中正式检验。
