Jin Chao, Hu Bobin, Liu Hongyu, Wang Rongming, Jang Jianning, Su Minghua
Infectious Diseases Department, The First Affiliated Hospital of Guangxi Medical University, Shuangyong Road, Nanning, 530021, China.
Sci Rep. 2025 May 22;15(1):17777. doi: 10.1038/s41598-025-98922-z.
We aimed to explore the effectiveness of CTH as a serum inflammation biomarker for HCC. Enzyme-linked immunosorbent assay was used to detect serum levels of CTH, interleukin-6 (IL-6), C-reactive protein (CRP), and IL-10. The Scheuer scoring system was used to assess the liver inflammation grading (significant liver inflammation: ≥ G2 grade). CTH levels in the HCC group were significantly elevated (P < 0.0001). Of 146 patients, 58.22% exhibited significant liver inflammation. CTH levels in patients with significant liver inflammation were significantly higher than those in patients with no or mild liver inflammation (< G 2) (p < 0.0001). The area under the Receiver Operating Characteristic (ROC) curve for CTH in predicting significant hepatitis was 0.77 (sensitivity, 81.2%; specificity,62.3%). There was a significant positive correlation (r = 0.50, p < 0.05) between serum CTH levels and histopathological parameter G. The area under the ROC curve for CTH in predicting hepatocellular carcinoma was 0.83 (sensitivity, 64.6%; specificity, 83.3%). CTH and AFP improved the diagnostic accuracy of HCC. CTH levels significantly decreased 6 months post-operation (p < 0.05). The recurrence of HCC caused significant increases in CTH levels. Thus, CTH can serve as a serum inflammation marker for HCC.
我们旨在探讨CTH作为肝细胞癌血清炎症生物标志物的有效性。采用酶联免疫吸附测定法检测血清CTH、白细胞介素-6（IL-6）、C反应蛋白（CRP）和IL-10水平。使用Scheuer评分系统评估肝脏炎症分级（显著肝脏炎症：≥G2级）。肝细胞癌组的CTH水平显著升高（P<0.0001）。146例患者中，58.22%表现出显著肝脏炎症。有显著肝脏炎症的患者的CTH水平显著高于无或轻度肝脏炎症（<G2）的患者（p<0.0001）。CTH预测显著肝炎的受试者工作特征（ROC）曲线下面积为0.77（敏感性，81.2%；特异性，62.3%）。血清CTH水平与组织病理学参数G之间存在显著正相关（r=0.50，p<0.05）。CTH预测肝细胞癌的ROC曲线下面积为0.83（敏感性，64.6%；特异性，83.3%）。CTH和甲胎蛋白提高了肝细胞癌的诊断准确性。术后6个月CTH水平显著降低（p<0.05）。肝细胞癌复发导致CTH水平显著升高。因此，CTH可作为肝细胞癌的血清炎症标志物。
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