与年龄相关的任务相关网络、负性网络活动增加及数字归纳推理。
Age-related increase in brain activity during task-related and -negative networks and numerical inductive reasoning.
作者信息
Sun Li, Liang Peipeng, Jia Xiuqin, Qi Zhigang, Li Kuncheng
机构信息
Department of Radiology, Xuan Wu Hospital, Capital Medical University Beijing 100053, China.
出版信息
Int J Clin Exp Pathol. 2014 Aug 15;7(9):5960-7. eCollection 2014.
OBJECTIVE
Recent neuroimaging studies have shown that elderly adults exhibit increased and decreased activation on various cognitive tasks, yet little is known about age-related changes in inductive reasoning.
METHODS
To investigate the neural basis for the aging effect on inductive reasoning, 15 young and 15 elderly subjects performed numerical inductive reasoning while in a magnetic resonance (MR) scanner.
RESULTS
Functional magnetic resonance imaging (fMRI) analysis revealed that numerical inductive reasoning, relative to rest, yielded multiple frontal, temporal, parietal, and some subcortical area activations for both age groups. In addition, the younger participants showed significant regions of task-induced deactivation, while no deactivation occurred in the elderly adults. Direct group comparisons showed that elderly adults exhibited greater activity in regions of task-related activation and areas showing task-induced deactivation (TID) in the younger group.
CONCLUSIONS
Our findings suggest an age-related deficiency in neural function and resource allocation during inductive reasoning.
目的
近期的神经影像学研究表明，老年人在各种认知任务中表现出激活增加和减少的情况，但对于归纳推理中与年龄相关的变化知之甚少。
方法
为了研究衰老对归纳推理影响的神经基础，15名年轻受试者和15名老年受试者在磁共振（MR）扫描仪中进行数字归纳推理。
结果
功能磁共振成像（fMRI）分析显示，相对于静息状态，数字归纳推理在两个年龄组中均产生了多个额叶、颞叶、顶叶和一些皮质下区域的激活。此外，年轻参与者表现出显著的任务诱导失活区域，而老年人未出现失活情况。直接组间比较显示，老年人在任务相关激活区域和年轻组中显示任务诱导失活（TID）的区域表现出更大的活动。
结论
我们的研究结果表明，在归纳推理过程中存在与年龄相关的神经功能和资源分配缺陷。
Zotero 插件