Yamada Masatoshi, Katano Harutaka, Yotsumoto Mihoko, Hashimoto Hirotsugu, Muramatsu Takashi, Shiotsuka Mika, Fukutake Katsuyuki, Kuroda Masahiko
Department of Molecular Pathology, Tokyo Medical University Tokyo, Japan.
Department of Pathology, National Institute of Infectious Disease Tokyo, Japan.
Int J Clin Exp Pathol. 2014 Aug 15;7(9):6415-8. eCollection 2014.
Human herpesvirus 8 (HHV8)-positive plasmablastic lymphoma is a disease which correlates with acquired immunodeficiency syndrome (AIDS). Little is known about the pathogenesis of the disease due to its rarity. We report an autopsy case about AIDS related HHV-8-positive plasmablastic lymphoma and presents an examination about HHV8 related proteins for the disease by using immunohistochemical techniques.
Two kinds of tumors complicated the male AIDS patient: one was HHV-8-positive plasmablastic lymphoma and the other was Kaposi's sarcoma (KS). Immunohistochemically, the lymphoma cells were positive for HHV8-associated lytic early proteins as well as HHV8 latency-associated nuclear antigen 1 (LANA-1), and, on the other hand, the lymphoma cells were negative for lytic immediately early proteins. KS was positive for only LANA-1.
These findings indicate that the lymphoma cells acquired an ability to proliferate without de novo HHV8 replication. Moreover, the onset mechanisms of HHV-8-positive plasmablastic lymphoma may be different from those of KS.
人疱疹病毒8型（HHV8）阳性浆母细胞淋巴瘤是一种与获得性免疫缺陷综合征（AIDS）相关的疾病。由于其罕见性，对该疾病的发病机制知之甚少。我们报告一例与艾滋病相关的HHV - 8阳性浆母细胞淋巴瘤的尸检病例，并运用免疫组化技术对该疾病中与HHV8相关的蛋白进行检测。
该男性艾滋病患者并发两种肿瘤：一种是HHV - 8阳性浆母细胞淋巴瘤，另一种是卡波西肉瘤（KS）。免疫组化结果显示，淋巴瘤细胞对HHV8相关的裂解早期蛋白以及HHV8潜伏相关核抗原1（LANA - 1）呈阳性，另一方面，淋巴瘤细胞对裂解即刻早期蛋白呈阴性。KS仅对LANA - 1呈阳性。
这些发现表明淋巴瘤细胞获得了在无HHV8重新复制情况下增殖的能力。此外，HHV - 8阳性浆母细胞淋巴瘤的发病机制可能与KS不同。
