Moore P S, Boshoff C, Weiss R A, Chang Y
School of Public Health, Columbia University, New York, NY 10032, USA.
Science. 1996 Dec 6;274(5293):1739-44. doi: 10.1126/science.274.5293.1739.
Four virus proteins similar to two human macrophage inflammatory protein (MIP) chemokines, interleukin-6 (IL-6), and interferon regulatory factor (IRF) are encoded by the Kaposi's sarcoma-associated herpesvirus (KSHV) genome. vIL-6 was functional in B9 proliferation assays and primarily expressed in KSHV-infected hematopoietic cells rather than KS lesions. HIV-1 transmission studies showed that vMIP-I is similar to human MIP chemokines in its ability to inhibit replication of HIV-1 strains dependent on the CCR5 co-receptor. These viral genes may form part of the response to host defenses contributing to virus-induced neoplasia and may have relevance to KSHV and HIV-I interactions.
卡波西肉瘤相关疱疹病毒（KSHV）基因组编码了四种与两种人类巨噬细胞炎性蛋白（MIP）趋化因子、白细胞介素-6（IL-6）和干扰素调节因子（IRF）相似的病毒蛋白。vIL-6在B9增殖试验中具有功能，主要在KSHV感染的造血细胞中表达，而非卡波西肉瘤病变中。HIV-1传播研究表明，vMIP-I在抑制依赖CCR5共受体的HIV-1毒株复制的能力方面与人类MIP趋化因子相似。这些病毒基因可能构成对宿主防御反应的一部分，促成病毒诱导的肿瘤形成，并且可能与KSHV和HIV-1的相互作用有关。
