葫芦[8]脲诱导形成的紧密超分子蛋白质二聚体的溶液结构
Solution structure of a cucurbit[8]uril induced compact supramolecular protein dimer.
作者信息
Dang Dung T, Bosmans Ralph P G, Moitzi Christian, Voets Ilja K, Brunsveld Luc
机构信息
Department of Biomedical Engineering, Eindhoven University of Technology, Den Dolech 2, 5612 AZ, Eindhoven, The Netherlands.
出版信息
Org Biomol Chem. 2014 Dec 14;12(46):9341-4. doi: 10.1039/c4ob01729c. Epub 2014 Oct 22.
Supramolecular assembly of a beta-barrel protein via cucurbit[8]uril results in compact z-shaped protein dimers. SAXS data reveal the formation of a well ordered protein dimer, notwithstanding being connected by a reversible and flexible peptide linker, and highlight the supramolecular induced interplay of the proteins, analogous to covalently linked proteins.
通过葫芦[8]脲形成的β-桶状蛋白超分子组装体产生紧密的Z形蛋白二聚体。小角X射线散射数据揭示了尽管由可逆且灵活的肽接头连接，但仍形成了有序的蛋白二聚体，并突出了超分子诱导的蛋白间相互作用，类似于共价连接的蛋白。
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