Xia Lingzi, Ren Yangwu, Fang Xue, Yin Zhihua, Li Xuelian, Wu Wei, Guan Peng, Zhou Baosen
Department of Epidemiology, School of Public Health, China Medical University, Shenyang, Liaoning Province, China; Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, Shenyang, China.
PLoS One. 2014 Oct 22;9(10):e106799. doi: 10.1371/journal.pone.0106799. eCollection 2014.
The morbidity and mortality of cancer increase remarkably every year. It's a heavy burden for family and society. The detection of prognostic biomarkers can help to improve the theraputic effect and prolong the lifetime of patients. microRNAs have an influential role in cancer prognosis. The results of articles discussing the relationship between microRNA polymorphisms and cancer prognosis are inconsistent.
We conduct a meta-analysis of 19 publications concerning the association of four common polymorphisms, mir-146a rs2910164, mir-149 rs2292832, mir-196a2 rs11614913 and mir-499 rs3746444, with cancer prognosis. Pooled Hazard Ratios with 95% Confidence Intervals for the relationship between four genetic polymorphisms and Overall Survival, Recurrence-free Survival, Disease-free survival, recurrence are calculated. Subgroup analysis by population and type of tumor are conducted.
GG genotype of mir-146a may be the protective factor for overall survival, especially in Caucasian population. C-containing genotypes of mir-196a2 act as a risk role for overall survival. The same result exists in Asian population, in Non-Small Cell Lung Cancer and digestive cancer. The patients with C allele of mir-149 have a better overall survival, especially in Non-Small Cell Lung Cancer. No significant results are obtained for mir-499 polymorphisms.
Genetic polymorphisms in mir-146a, mir-196a2 and mir-149 may be associated with overall survival. This effect varies with different types of cancer. Genetic polymorphism in mir-499 may have nothing to do with cancer prognosis.
癌症的发病率和死亡率每年都显著增加。这给家庭和社会带来了沉重负担。预后生物标志物的检测有助于提高治疗效果并延长患者寿命。微小RNA在癌症预后中具有重要作用。关于微小RNA多态性与癌症预后关系的文章结果并不一致。
我们对19篇关于四种常见多态性（mir-146a rs2910164、mir-149 rs2292832、mir-196a2 rs11614913和mir-499 rs3746444）与癌症预后关联的出版物进行了荟萃分析。计算了四种基因多态性与总生存期、无复发生存期、无病生存期、复发之间关系的合并风险比及95%置信区间。按人群和肿瘤类型进行了亚组分析。
mir-146a的GG基因型可能是总生存期的保护因素，尤其是在白种人群中。mir-196a2含C的基因型对总生存期起风险作用。在亚洲人群、非小细胞肺癌和消化系统癌症中也存在相同结果。mir-149 C等位基因的患者总生存期较好，尤其是在非小细胞肺癌中。mir-499多态性未获得显著结果。
mir-146a、mir-196a2和mir-149中的基因多态性可能与总生存期相关。这种效应因癌症类型而异。mir-499中的基因多态性可能与癌症预后无关。
