Wan D, Gu W, Xu G, Shen C, Ding D, Shen S, Wang S, Gong X, He S, Zhi Q
Department of Hepatobiliary Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510006, Guangdong, China.
Clin Transl Oncol. 2014 Sep;16(9):792-800. doi: 10.1007/s12094-013-1150-x. Epub 2014 Jan 8.
Emerging evidence has shown that single nucleotide polymorphisms occurred in microRNAs may contribute to the development of colorectal cancer (CRC). rs2910164 in miR-146a and rs11614913 in miR-196a2 are suggested to be associated with the susceptibility to CRC, but individually published studies revealed inconclusive results. To systematically summarize the possible correlationship between these polymorphisms and CRC risk, we performed this meta-analysis.
We retrieved the relevant articles of the associations between these two microRNA polymorphisms and susceptibility to CRC for the period up to July 1, 2013. A total of seven articles were identified with 2,143 cases and 2,457 controls for miR-146a rs2910164, 1,594 cases and 2,252 controls for miR-196a2 rs11614913. Odds ratio and 95 % confidence interval were calculated to investigate the strength of the association.
The pooled analysis showed that miR-146a rs2910164 did not reveal any correlation with CRC susceptibility. However, a decreased risk was observed between miR-196a2 rs11614913 and CRC in all genetic models.
Our current meta-analysis demonstrates that miR-196a2 rs11614913 most likely contributes to decreased risk of CRC, whereas miR-146a rs2910164 may not be associated with the susceptibility to CRC.
新出现的证据表明，微小RNA中发生的单核苷酸多态性可能与结直肠癌（CRC）的发生有关。miR-146a中的rs2910164和miR-196a2中的rs11614913被认为与CRC易感性相关，但个别发表的研究结果并不确定。为了系统总结这些多态性与CRC风险之间的可能相关性，我们进行了这项荟萃分析。
我们检索了截至2013年7月1日这两种微小RNA多态性与CRC易感性之间关联的相关文章。共鉴定出7篇文章，其中miR-146a rs2910164有2143例病例和2457例对照，miR-196a2 rs11614913有1594例病例和2252例对照。计算比值比和95%置信区间以研究关联强度。
汇总分析表明，miR-146a rs2910164与CRC易感性无任何相关性。然而，在所有遗传模型中，miR-196a2 rs11614913与CRC之间的风险降低。
我们目前的荟萃分析表明，miR-196a2 rs11614913很可能有助于降低CRC风险，而miR-146a rs2910164可能与CRC易感性无关。
