磷脂酶A2和环氧化酶抑制对大脑中游离脂肪酸的影响。

The effect of phospholipase A2 and cyclooxygenase inhibition on free fatty acids in the brain.

作者信息

Sklenovský A, Navrátil J, Chmela Z

出版信息

Acta Univ Palacki Olomuc Fac Med. 1989;121:253-60.

Abstract

The levels of NEFA (oleic acid, palmitic acid, stearic acid, arachidonic acid) were studied in the brain cortex, hypothalamus and the brain stem of rat brain. Inhibition of phospholipase A2 by Delagil (Mepacrinium dichloratum CsL 3) decreased statistically significantly the values of arachidonic aci (-5.5%) in the brain cortex and the values of stearic acid (-11.2%) in the hypothalamua. The cyclooxygenase inhibition by aspirin led to a significant increase of palmitic acid (+12.7%), oleic acid (+18.7%) and arachidonic acid (+14.3%) in the hypothalamus. Total NEFA increased by 11.2%. A significant increase of palmitic acid (+26.9%), arachidonic acid (+33.9%) and of total NEFA (+22.9%) was evidenced in the brain stem. Delagil administered in combination with acetylsalicylic acid suppressed the NEFA increase observed after the application of acetylsalicylic acid alone. A statistically significant decrease was found in stearic acid (-12.6%) in the hypothalamus and in all studied NEFA in the brain stem (palmitic acid, -14.2% stearic acid -11.7%, oleic acid -3.8%, arachidonic acid -16.6% and total NEFA -11.8%).

摘要

研究了大鼠大脑皮层、下丘脑和脑干中游离脂肪酸（油酸、棕榈酸、硬脂酸、花生四烯酸）的水平。德拉吉尔（二氯甲喹嗡CsL 3）对磷脂酶A2的抑制作用使大脑皮层中花生四烯酸的值（-5.5%）和下丘脑中硬脂酸的值（-11.2%）在统计学上显著降低。阿司匹林对环氧化酶的抑制导致下丘脑中棕榈酸（+12.7%）、油酸（+18.7%）和花生四烯酸（+14.3%）显著增加。游离脂肪酸总量增加了11.2%。脑干中棕榈酸（+26.9%）、花生四烯酸（+33.9%）和游离脂肪酸总量（+22.9%）显著增加。德拉吉尔与乙酰水杨酸联合使用可抑制单独应用乙酰水杨酸后观察到的游离脂肪酸增加。下丘脑中硬脂酸（-12.6%）以及脑干中所有研究的游离脂肪酸（棕榈酸，-14.2%；硬脂酸，-11.7%；油酸，-3.8%；花生四烯酸，-16.6%；游离脂肪酸总量，-11.8%）在统计学上显著降低。