Effects of single administration of scopolamine, physostigmine and their combination on biogenic amine levels in rat brain.

There were studied the changes of norepinephrine and dopamine levels in the brain cortex, the brain stem and hypothalamus of rats after the application of scopolamine, physostigmine and their combination. The application of scopolamine (0.5 mg/kg) or physostigmine (1.0 mg/kg) increased the levels of NE and in many cases statistically significantly. The simultaneous application of both drugs was manifested by less marked or neglectable changes of NE and DA levels in comparison with the control group.