Zubrikhina G N, Blinder V N, Matveyeva I I
Klin Lab Diagn. 2014 May(5):21-5.
The clinical blood analysis implemented at modern hematological analyzers can be used as a foundation for primary differentiated diagnostic of anemic syndrome related to true and functional iron deficiency in oncologic patients. The normocyte normochromic anemia with normal and higher level of hemoglobin of reticulocytes (RET-HE) testifies presence in higher degree of anemia of chronic diseases which is more often combined with higher content of serum ferritin (Ferr), lower level of soluble receptors of ferritin (sTfR) and production of erythropoietin (EPO) inadequate to anemia degree. The microcyte hypochromic anemia can be present both under iron-deficient anemia and under functional iron deficiency as a result of its blocking in macrophages under anemia of chronic diseases in oncologic patients. Hence the differentiated diagnostic of these states demands additional analysis of content of serum ferritin, soluble receptors of ferritin and production of erythropoietin.
现代血液分析仪进行的临床血液分析可作为肿瘤患者真性和功能性缺铁性贫血综合征初步鉴别诊断的基础。正细胞正色素性贫血且网织红细胞血红蛋白（RET-HE）水平正常或升高，提示存在较高程度的慢性病贫血，这种贫血更常与血清铁蛋白（Ferr）含量升高、铁蛋白可溶性受体（sTfR）水平降低以及促红细胞生成素（EPO）生成量与贫血程度不匹配相关。小细胞低色素性贫血在缺铁性贫血和功能性缺铁时均可出现，后者是由于肿瘤患者慢性病贫血时巨噬细胞对铁的阻滞作用所致。因此，对这些状态进行鉴别诊断需要额外分析血清铁蛋白含量、铁蛋白可溶性受体以及促红细胞生成素的生成情况。
