Esumi Satoru, Kawasaki Yoichi, Gomita Yutaka, Kitamura Yoshihisa, Sendo Toshiaki
Department of Pharmacy, Okayama University Hospital, Okayama 700-8558, Japan.
Acta Med Okayama. 2014;68(5):255-62. doi: 10.18926/AMO/52893.
Motivation incorporates several psychological aspects that produce reward-related and learning behaviors. Although reward-related behavior is reported to be mediated by the dopaminergic reward pathway, the involvement of dopaminergic systems in motivated behavior has not been fully clarified. Several experimental methodologies for motivational behavior have been reported, but pharmacological characteristics seem to vary among these methodologies. In this review, we attempt to summarize three main concepts:(1) the relationship of dopamine neuron physiology with motivated behavior, (2) the pharmacological characteristics of the runway intracranial self-stimulation model, and (3) the behavioral distinction of disparate motivated behaviors.
动机包含几个产生与奖励相关及学习行为的心理方面。尽管据报道与奖励相关的行为是由多巴胺能奖励通路介导的，但多巴胺能系统在动机行为中的作用尚未完全阐明。已经报道了几种用于动机行为的实验方法，但这些方法的药理学特征似乎各不相同。在这篇综述中，我们试图总结三个主要概念：（1）多巴胺神经元生理学与动机行为的关系，（2）跑道颅内自我刺激模型的药理学特征，以及（3）不同动机行为的行为差异。
