[培养的人结肠癌细胞中α干扰素受体的证明]
[Demonstration of an interferon alpha receptor in human colonic cancer cells in culture].
作者信息
Boissard C, Chelbi Alix M K, Gali P, Thang M N, Rosselin G
出版信息
C R Acad Sci III. 1989;309(11):485-92.
PMID:2533880
Abstract
The IFN-alpha 2 receptor present in human cancerous colonic cells in culture has a capacity of 1,800 sites per cell with a kd of 0.5 nM. The molecular mass of the interferon alpha 2 (IFN-alpha 2) receptor complex is 134 kd. The IFN-alpha 2 induces the activity of the 2'5' oligoadenylate (2'5' A) synthetase activity in these cells and partly inhibits their growth.
摘要
培养的人结肠癌细胞中存在的α-干扰素2受体，每个细胞有1800个位点，解离常数为0.5纳摩尔。α-干扰素2（IFN-α2）受体复合物的分子量为134千道尔顿。IFN-α2可诱导这些细胞中2',5'-寡腺苷酸（2'5'A）合成酶的活性，并部分抑制其生长。
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