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吉隆坡针对处于癌症康复期女性的气功试验——一项三臂随机对照试验改善生活质量的疗效

The Kuala Lumpur Qigong trial for women in the cancer survivorship phase-efficacy of a three-arm RCT to improve QOL.

作者信息

Loh Siew Yim, Lee Shing Yee, Murray Liam

机构信息

Department of Rehabilitation Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia E-mail :

出版信息

Asian Pac J Cancer Prev. 2014;15(19):8127-34. doi: 10.7314/apjcp.2014.15.19.8127.

DOI:10.7314/apjcp.2014.15.19.8127
PMID:25338995
Abstract

BACKGROUND

Qigong is highly favoured among Asian breast cancer survivors for enhancing health. This study examined the hypothesis that quality of life (QoL) in the Qigong group is better than the placebo (aerobic) or usual care group.

MATERIALS AND METHODS

A total of 197 participants were randomly assigned to either the 8-week Kuala Lumpur Qigong Trial or control groups in 2010-2011. Measurement taken at baseline and post- intervention included QoL, distress and fatigue. Analysis of covariance (ANCOVA) and Kruskal Wallis were used to examine for differences between groups in the measurements.

RESULTS

There were 95 consenting participants in this 8week trial. The adherence rates were 63% for Qigong and 65% for the placebo group. The Qigong group showed significant marginal improvement in Quality of life scores compared to placebo (mean difference=7.3 unit; p=0.036), compared to usual care (mean difference=6.7 unit; p=0.048) on Functional Assessment Cancer Therapy-Breast measure. There were no significant changes between the placebo and usual care groups in fatigue or distress at post intervention (8-week).

CONCLUSIONS

Cancer survivors who participated in the Qigong intervention showed slightly better QOL. Follow up studies are greatly needed to evaluate which subgroups may best benefit from Qigong. With a steep rise of cancer survivors, there is an urgent need to explore and engage more cultural means of physical activity to fight side effects of treatment and for cancer control in developing countries.

摘要

背景

气功在亚洲乳腺癌幸存者中备受青睐,用于增进健康。本研究检验了以下假设:气功组的生活质量(QoL)优于安慰剂(有氧运动)组或常规护理组。

材料与方法

2010 - 2011年,共有197名参与者被随机分配至为期8周的吉隆坡气功试验组或对照组。在基线和干预后进行的测量包括生活质量、痛苦和疲劳。采用协方差分析(ANCOVA)和克鲁斯卡尔 - 沃利斯检验来检查各组在测量结果上的差异。

结果

在这个为期8周的试验中有95名参与者同意参与。气功组的依从率为63%,安慰剂组为65%。在癌症治疗功能评估 - 乳腺测量中,与安慰剂组相比,气功组的生活质量得分有显著的边际改善(平均差异 = 7.3单位;p = 0.036),与常规护理组相比(平均差异 = 6.7单位;p = 0.048)。干预后(8周),安慰剂组和常规护理组在疲劳或痛苦方面没有显著变化。

结论

参与气功干预的癌症幸存者的生活质量略好。非常需要进行后续研究,以评估哪些亚组可能最受益于气功。随着癌症幸存者数量的急剧增加,迫切需要探索和采用更多文化形式的体育活动,以对抗治疗的副作用并在发展中国家进行癌症控制。

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