Tanimura Kenji, Tairaku Shinya, Deguchi Masashi, Sonoyama Ayako, Morizane Mayumi, Ebina Yasuhiko, Morioka Ichiro, Yamada Hideto
Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.
Kobe J Med Sci. 2014 Jul 11;60(2):E25-9.
The aim of this trial study was to assess the preventive efficacy of immunoglobulin with a high titer of anti-CMV antibody for mother-to-fetus cytomegalovirus (CMV) transmission among pregnant women with primary/acute CMV infection. The primary CMV infection in mothers was diagnosed by a positive test for CMV IgM and/or low IgG avidity. Intact type immunoglobulin with a high titer of anti-CMV antibody was injected intravenously at a dosage of 2.5-5.0 g/day for consecutive 3 days to mothers with primary CMV infection. Four pregnant women were enrolled. One pregnancy ended in no congenital infection, while two pregnancies ended in congenital CMV infection. The other one pregnancy was terminated. The mother-to-fetus CMV transmission rate was found to be high as 66.7% (2/3). This preliminary result suggests that intravenous immunoglobulin injections are not effective for the prevention of mother-to-fetus CMV transmission in the present protocol.
本试验研究的目的是评估高滴度抗巨细胞病毒（CMV）抗体免疫球蛋白对原发性/急性CMV感染孕妇母婴CMV传播的预防效果。母亲的原发性CMV感染通过CMV IgM检测呈阳性和/或低IgG亲和力来诊断。对原发性CMV感染的母亲静脉注射高滴度抗CMV抗体的完整型免疫球蛋白，剂量为2.5 - 5.0 g/天，连续3天。招募了4名孕妇。1例妊娠未发生先天性感染，2例妊娠发生先天性CMV感染。另一例妊娠终止。母婴CMV传播率高达66.7%（2/3）。这一初步结果表明，按照本方案静脉注射免疫球蛋白对预防母婴CMV传播无效。
