Liu W K, Mak N K, Wong C C
Department of Anatomy, Faculty of Medicine, Chinese University of Hong Kong.
Immunobiology. 1989 Nov;180(1):23-32. doi: 10.1016/S0171-2985(89)80027-0.
The effects of antithyroid drug, methimazole (MMI, 1-methyl-2-mercaptoimidazole), on the immune system of inbred mice, C57BL/6, were studied. The proliferative response of splenic lymphocytes to concanavalin A (Con A) and allogeneic stimulator cells was reduced when the mice were provided with 0.1% MMI in tap water ad libitum for two to four weeks. The reduction of proliferative response was correlated with a lower frequency of proliferative spleen cells in the MMI-treated mice. The ability to produce macrophage activating factor of these spleen cells and the levels of hemolytic plaque-forming cells were also reduced. However, the mitogenic response of the splenic lymphocytes to lipopolysaccharide (LPS) was enhanced. In order to investigate whether the impaired cell-mediated and humoral immune systems would increase the susceptibility of the MMI-treated animal to the growth of tumor cells, mice were challenged with a lethal dose of Moloney virus-induced T cell lymphoma of C57BL/6 mice (MBL-2). The time required for 50% of the animals to die was reduced from 15 days for the normal mice to 10 days for the MMI-treated mice.
研究了抗甲状腺药物甲巯咪唑（MMI，1-甲基-2-巯基咪唑）对近交系小鼠C57BL/6免疫系统的影响。当给小鼠随意饮用含0.1%MMI的自来水持续两到四周时，脾淋巴细胞对刀豆球蛋白A（Con A）和同种异体刺激细胞的增殖反应降低。增殖反应的降低与MMI处理组小鼠中增殖脾细胞频率较低相关。这些脾细胞产生巨噬细胞活化因子的能力以及溶血空斑形成细胞的水平也降低了。然而，脾淋巴细胞对脂多糖（LPS）的促有丝分裂反应增强。为了研究细胞介导和体液免疫系统受损是否会增加MMI处理动物对肿瘤细胞生长的易感性，用致死剂量的莫洛尼病毒诱导的C57BL/6小鼠T细胞淋巴瘤（MBL-2）攻击小鼠。50%的动物死亡所需时间从正常小鼠的15天缩短至MMI处理组小鼠的10天。
