In S, Le Lann A D, Fournie G J, Benoist H
INSERM Unité-395, Toulouse, France.
Immunopharmacol Immunotoxicol. 1995 Aug;17(3):529-50. doi: 10.3109/08923979509016385.
Acebutolol induces transient polyclonal B cell activation in C57B1/6 mice but down-modulates the spontaneous polyclonal activation of NZBxNZW lupus mice. The immunomodulatory effects of this beta-blocker were studied in C57l/6 mice injected with LPS or immunized with sheep red blood cells. The effect of acebutolol on the polyclonal activation of lymphocytes induced by LPS was also investigated in heterozygous and nu/nu C57BL/6 mice. Finally, the direct effect of acebutolol on spleen cells was studied in vitro. Acebutolol treatment for 15 days (50mg/kg/day) inhibited the polyclonal activation of lymphocytes induced by LPS in C57BL/6 and in C57BI/6 nu/nu mice, but increased the humoral response to sheep red blood cells in C57Bl/6 mice. Moreover, spleen cells from C57Bl/6 mice treated for 15 days with acebutolol showed an increased number of CD5+ and CD4+ lymphocytes, as well as an increased reactivity to concanavalin A but not to LPS. In vitro, acebutolol at 10(-5)-10(-7) M induced an increased reactivity of spleen cells from naive mice to concanavalin A, whereas it did not affect the B cell responsiveness to LPS. These results indicate that acebutolol modulates both T-cells and non T-cells in the immune system.
醋丁洛尔可诱导C57B1/6小鼠出现短暂的多克隆B细胞激活，但可下调NZBxNZW狼疮小鼠的自发多克隆激活。在注射脂多糖（LPS）或用绵羊红细胞免疫的C57l/6小鼠中研究了这种β受体阻滞剂的免疫调节作用。还在杂合子和裸鼠（nu/nu）C57BL/6小鼠中研究了醋丁洛尔对LPS诱导的淋巴细胞多克隆激活的影响。最后，在体外研究了醋丁洛尔对脾细胞的直接作用。醋丁洛尔连续治疗15天（50mg/kg/天）可抑制C57BL/6和C57BI/6裸鼠中LPS诱导的淋巴细胞多克隆激活，但增强了C57Bl/6小鼠对绵羊红细胞的体液反应。此外，用醋丁洛尔治疗15天的C57Bl/6小鼠的脾细胞显示CD5+和CD4+淋巴细胞数量增加，以及对刀豆球蛋白A的反应性增加，但对LPS的反应性未增加。在体外，10(-5)-10(-7)M的醋丁洛尔可诱导未免疫小鼠的脾细胞对刀豆球蛋白A的反应性增加，而不影响B细胞对LPS的反应性。这些结果表明醋丁洛尔可调节免疫系统中的T细胞和非T细胞。
