Syed Farah, Chandravanshi Lalit P, Khanna Vinay K, Soni Inderpal
Environmental Toxicology Laboratory, Department of Zoology, University of Rajasthan, Jaipur, 302004, India.
CSIR - Indian Institute of Toxicology Research, Post Box 80, MG Marg, Lucknow, 226001, India; Biochemistry Section, Department of Zoology, Banaras Hindu University, Varanasi, 221005, India.
Chem Biol Interact. 2016 Jan 5;243:19-28. doi: 10.1016/j.cbi.2015.11.015. Epub 2015 Nov 19.
Beta-cyfluthrin (CYF) is a commonly used synthetic pyrethroid having both agricultural and domestic applications. The present study aimed to evaluate the neurobehavioural effects of beta-cyfluthrin in adult rats administered at doses 25 mg/kg body weight/day and 12.5 mg/kg body weight/day for a period of 30 days. Motor coordination and spatial memory were found to be impaired by beta-cyfluthrin. Levels of dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), epinephrine (EPN), and serotonin (5-HT) decreased in frontal cortex, corpus striatum and hippocampus of treated rats. At the same time, significantly elevated levels of homovanillic acid (HVA) and nor-epinephrine (NE) were measured. Beta-cyfluthrin inhibited the activity of acetylcholinesterase (AChE) in all the regions of the brain. Hippocampal choline acetyltransferase (ChAT) expression was reduced 3.1 and 4.7 fold by the two doses respectively. Impairment of the antioxidant defense system, evident by decrease in the levels of antioxidant enzymes: superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) was seen in the treated rats. The neurochemical alterations manifested were more pronounced in the high dose group as the effects persisted even after withdrawal of exposure.
高效氟氯氰菊酯（CYF）是一种常用的合成拟除虫菊酯，具有农业和家庭应用。本研究旨在评估以25毫克/千克体重/天和12.5毫克/千克体重/天的剂量给成年大鼠连续给药30天，高效氟氯氰菊酯对其神经行为的影响。发现高效氟氯氰菊酯会损害运动协调能力和空间记忆。在接受治疗的大鼠的额叶皮质、纹状体和海马体中，多巴胺（DA）、3,4-二羟基苯乙酸（DOPAC）、肾上腺素（EPN）和血清素（5-HT）的水平降低。与此同时，检测到高香草酸（HVA）和去甲肾上腺素（NE）的水平显著升高。高效氟氯氰菊酯抑制了大脑所有区域的乙酰胆碱酯酶（AChE）的活性。两种剂量分别使海马体胆碱乙酰转移酶（ChAT）的表达降低了3.1倍和4.7倍。在接受治疗的大鼠中，抗氧化防御系统受损，表现为抗氧化酶超氧化物歧化酶（SOD）、过氧化氢酶（CAT）和谷胱甘肽过氧化物酶（GPx）的水平降低。在高剂量组中，神经化学改变更为明显，因为即使在停止接触后，这些影响仍然存在。
