Sepici-Dinçel Aylin, Cağlan Karasu Benli A, Selvi Mahmut, Sarikaya Rabia, Sahin Duygu, Ayhan Ozkul I, Erkoç Figen
Department of Medical Biochemistry, Faculty of Medicine, Gazi University, Ankara, Turkey.
Ecotoxicol Environ Saf. 2009 Jul;72(5):1433-9. doi: 10.1016/j.ecoenv.2009.01.008. Epub 2009 Mar 14.
This study measures a whole series of biological endpoints, and histopathological and behavioral changes of carp (Cyprinus carpio L.) fingerlings in order to investigate the adverse effects of a sublethal concentration of 10 microg/L cyfluthrin for 48h and one week using the semi-static test system. The most significantly altered findings of this study was that total antioxidant status levels decreased in 48h, chloride levels decreased in one week, and sodium and phosphorous levels increased in the 48h-exposed group. Plasma cortisol increased in both the 48h-exposed and the one-week-exposed groups. The unique tissue was the brain that had an increased level of malondialdehyde after one week of exposure. Such biomarkers may be used in assessing adverse/toxic effects of pesticides as environmental stressors. Potential oxidative-stress-inducing effect of synthetic pyrethroid cyfluthrin, as lipid peroxidation, in addition to its sodium channel blocking, is reported for the first time as an additional mechanism of action.
本研究测量了一系列生物学终点指标，以及鲤鱼（Cyprinus carpio L.）幼鱼的组织病理学和行为变化，以便使用半静态试验系统研究10微克/升氯氟氰菊酯亚致死浓度暴露48小时和一周的不良影响。本研究中最显著的变化结果是，48小时时总抗氧化状态水平下降，一周时氯离子水平下降，48小时暴露组的钠和磷水平升高。48小时暴露组和一周暴露组的血浆皮质醇均升高。唯一有变化的组织是大脑，暴露一周后丙二醛水平升高。此类生物标志物可用于评估作为环境应激源的农药的不良/毒性作用。首次报道了合成拟除虫菊酯氯氟氰菊酯除了具有钠通道阻断作用外，还具有潜在的氧化应激诱导作用，即脂质过氧化，这是其另一种作用机制。
