Rovisco João, Santiago Tânia, Inês Luís
Acta Reumatol Port. 2015 Jan-Mar;40(1):68-71.
Diffuse infiltrative lymphocytic syndrome is a clinical identity that can be part of the spectrum of Human Immunodeficiency Virus infection. It is characterized by sicca symptoms, parotid and lachrymal enlargement and extra-articular manifestations. We report the case of a 60 years old woman with clinical sicca syndrome in association with leukopenia, positive anti-nuclear antibody (ANA) and polyclonal hypergammaglobulinemia. In the follow up the patient developed a mucosa-associated lymphoid tissue pulmonary neoplasm. Furthermore, the clinical surveys revealed human immunodeficiency virus (HIV) positive markers. In this particular case report, we must underline the clinical presentation of a sicca syndrome as a manifestation of the HIV infection, bearing in mind that, frequently, the differential diagnosis from other diseases, namely the Sjögren's syndrome, is a real challenge.
弥漫性浸润性淋巴细胞综合征是一种临床病症，可能是人类免疫缺陷病毒感染谱的一部分。其特征为干燥症状、腮腺和泪腺肿大以及关节外表现。我们报告一例60岁女性病例，该患者有临床干燥综合征，伴有白细胞减少、抗核抗体（ANA）阳性和多克隆高球蛋白血症。在随访过程中，患者发生了黏膜相关淋巴组织肺肿瘤。此外，临床检查显示人类免疫缺陷病毒（HIV）阳性标志物。在本病例报告中，我们必须强调干燥综合征作为HIV感染表现的临床特征，同时要记住，与其他疾病（即干燥综合征）进行鉴别诊断往往是一项真正的挑战。
