γδ T细胞作为结肠癌免疫治疗的一种潜在工具。

γδ T cells as a potential tool in colon cancer immunotherapy.

作者信息

Ramutton Thiranut, Buccheri Simona, Dieli Francesco, Todaro Matilde, Stassi Giorgio, Meraviglia Serena

机构信息

Department of Biopathology & Biomedical Methodologies, University of Palermo, Palermo, Italy.

出版信息

Immunotherapy. 2014;6(9):989-99. doi: 10.2217/imt.14.59.

DOI:10.2217/imt.14.59

PMID:25341120

Abstract

γδ T cells are capable of recognizing tumor cells and exert potent cellular cytotoxicity against a large range of tumors, including colon cancer. However, tumors utilize numerous strategies to escape recognition or killing by patrolling γδ T cells, such a downregulation of NKG2D ligands, MICA/B and ULBPs. Therefore, the combined upregulation of T-cell receptorand NKG2D ligands on tumor cells and induction of NKG2D expression on γδ T cells may greatly enhance tumor killing and unlock the functions of γδ T cells. Here, we briefly review current data on the mechanisms of γδ T-cell recognition and killing of colon cancer cells and propose that γδ T cells may represent a promising target for the design of novel and highly innovative immunotherapy in patients with colon cancer.

摘要

γδ T细胞能够识别肿瘤细胞，并对包括结肠癌在内的多种肿瘤发挥强大的细胞毒性作用。然而，肿瘤利用多种策略逃避巡逻γδ T细胞的识别或杀伤，如NKG2D配体、MICA/B和ULBPs的下调。因此，肿瘤细胞上T细胞受体和NKG2D配体的联合上调以及γδ T细胞上NKG2D表达的诱导可能会大大增强肿瘤杀伤作用并开启γδ T细胞的功能。在此，我们简要回顾了目前关于γδ T细胞识别和杀伤结肠癌细胞机制的数据，并提出γδ T细胞可能是结肠癌患者新型和高度创新免疫疗法设计的一个有前景的靶点。