Brănişteanu Daciana Elena, Stoleriu Gabriela, Oanţă A, Dorobăţ Carmen Mihaela, Petrariu F D, Anchidin Daniela Mihaela, Ciubotaru Florina Mihaela Filip, Brănişteanu D C
Rev Med Chir Soc Med Nat Iasi. 2014 Jul-Sep;118(3):817-22.
Herpes zoster (shingles) is a neurocutaneous viral disease, in recent years its incidence increasing throughout the world.
To study the incidence of herpes zoster among Iasi county patients requiring hospital admission and to analyze the clinical and epidemiological features and socioeconomic status of the study group.
Retrospective study of 158 patients admitted to the largest clinical dermatology department in North-eastern Romania, the Clinical Dermatology Department of the Iasi "Sf. Spiridon" University Emergency Hospital. The study was conducted over a period of five years and included the analysis of epidemiological data, socioeconomic status, clinical forms of disease, associated diseases, pathology reports for skin biopsy fragments, administered treatment, and disease course.
This study confirms that shingles is not a sex-specific disease, the female/male ratio being 1.22: 1. Most patients belonged to the age group 70-80 years, accounting for about 35% of all patients, followed by the age group 60-70 years (24.6% of cases). A slight increase in the number of cases was recorded in autumn and summer in patients living in rural areas. 1.3% of the cases were diagnosed both with the disseminated form of disease, and complications (eczematization, bacterial superinfection, skin necrosis). 7.6% of patients presented additional skin disorders (pityriasis versicolor, impetigo, psoriasis vulgaris, mucocutaneous candidiasis), which raised the suspicion of an immune deficiency predisposing to shingles. The absence or late initiation of specific antiviral therapy correlated with prolonged hospital stay up to 4-6 days. We found an association between the erythematous form of shingles and young age, while the hemorrhagic or necrotic forms were present in the elderly and/or ill patients. The course was favorable and the length of illness was significantly shortened when the treatment adequate to the clinical form was administered. Associated comorbidities (essential hypertension 38.6%, dyslipidemia 24.6%, diabetes, mellitus 9.49%, chronic venous disease, other skin diseases) represent a factor complicating the development of herpes zoster by the cumulative stress the body is exposed to.
The main statistically significant epidemiological data in the study group are: older age (over 60 years), associated diseases (which by the marked imbalances induced in the body increase the risk of varicella zoster virus reactivation) intense psychological stress. The following parameters did not change the risk of developing shingles: area of origin, sex, the season at disease onset, number of hospital days, and administered treatment. Early diagnosis and treatment of this disease is important for maintaining a good quality of life, to avoid complications, to limit the extent of the disease and its transmission to others.
带状疱疹是一种神经皮肤病毒性疾病，近年来其发病率在全球范围内呈上升趋势。
研究雅西县需住院治疗的患者中带状疱疹的发病率，并分析研究组的临床、流行病学特征及社会经济状况。
对罗马尼亚东北部最大的临床皮肤科——雅西“圣斯皮里东”大学急诊医院临床皮肤科收治的158例患者进行回顾性研究。该研究历时五年，包括对流行病学数据、社会经济状况、疾病临床类型、相关疾病、皮肤活检碎片的病理报告、所给予的治疗以及病程的分析。
本研究证实带状疱疹并非性别特异性疾病，女性与男性比例为1.22∶1。大多数患者属于70 - 80岁年龄组，约占所有患者的35%，其次是60 - 70岁年龄组（占病例的24.6%）。农村地区患者在秋季和夏季的病例数略有增加。1.3%的病例被诊断为播散型疾病及并发症（湿疹化、细菌重叠感染、皮肤坏死）。7.6%的患者出现其他皮肤疾病（花斑糠疹、脓疱疮、寻常型银屑病、皮肤黏膜念珠菌病），这增加了对易患带状疱疹的免疫缺陷的怀疑。特异性抗病毒治疗的缺失或延迟开始与住院时间延长至4 - 6天相关。我们发现带状疱疹的红斑型与年轻年龄有关，而出血型或坏死型多见于老年人和/或患病患者。当给予适合临床类型的治疗时，病程良好且疾病持续时间显著缩短。相关合并症（原发性高血压38.6%、血脂异常24.6%、糖尿病9.49%、慢性静脉疾病、其他皮肤病）是由于身体所承受的累积压力而使带状疱疹病情复杂化的一个因素。
研究组主要具有统计学意义的流行病学数据为：年龄较大（60岁以上）、相关疾病（因其在体内引起的明显失衡增加了水痘 - 带状疱疹病毒再激活的风险）、强烈的心理压力。以下参数未改变患带状疱疹的风险：发病地区、性别、发病季节、住院天数及所给予的治疗。对该疾病进行早期诊断和治疗对于维持良好生活质量、避免并发症、限制疾病范围及其传播给他人很重要。
