醛糖还原酶 I 在肿瘤细胞增殖和存活中的作用及其作为抗癌治疗潜在靶点的研究进展。

Glyoxalase I in tumor cell proliferation and survival and as a potential target for anticancer therapy.

机构信息

Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi, China.

出版信息

Oncol Res Treat. 2014;37(10):570-4. doi: 10.1159/000367800. Epub 2014 Sep 11.

DOI:10.1159/000367800

PMID:25342507

Abstract

Glyoxalase I (GLO1) belongs to the glyoxalase system, which catalyzes the conversion of deleterious methylglyoxal, mainly produced by glycolysis, to non-toxic D-lactate. The expression of GLO1 was up-regulated in tumor tissues with high metabolic rate, whereas inhibition of GLO1 expression led to the accumulation of glyoxal and methylglyoxal, significantly inducing cell damage or apoptosis. This suggests that GLO1 may play an important role in tumor cell proliferation and survival, and may represent a potential therapeutic target for tumors. Moreover, overexpression of GLO1 was associated with multidrug resistance in cancer chemotherapy. This review describes the role of GLO1 in tumor cell proliferation and survival, and the potential of GLO1 as a biomarker for tumor diagnosis and as a target for anticancer drug development.

摘要

一氧二甲醛酶 I（GLO1）属于一氧二甲醛酶系统，可催化有害的一氧二甲醛（主要由糖酵解产生）转化为无毒的 D-乳酸。在代谢率较高的肿瘤组织中，GLO1 的表达上调，而抑制 GLO1 的表达会导致一氧二甲醛和甲基乙二醛的积累，从而显著诱导细胞损伤或凋亡。这表明 GLO1 可能在肿瘤细胞增殖和存活中发挥重要作用，可能成为肿瘤治疗的潜在靶点。此外，GLO1 的过表达与癌症化疗中的多药耐药性有关。本综述描述了 GLO1 在肿瘤细胞增殖和存活中的作用，以及 GLO1 作为肿瘤诊断生物标志物和抗癌药物开发靶点的潜力。