Tchórzewski H, Zeman K, Baj Z, Płuzańska A, Chilarski A, Majewska E, Pokoca L, Bugała I, Kantorski J
Department of Pathophysiology, Pediatrics Surgery Medical School AM, Lódź, Poland.
Exp Clin Immunogenet. 1989;6(2):185-9.
Lymphocyte subpopulations and autologous mixed lymphocyte reaction (AMLR) studied in 13 hereditary sphereocytosis and 21 postsplenectomy patients; the operation was performed because of hereditary spherocytosis. Significant increases of Th cells and the Th/Ts ratio have been noted in children with hereditary spherocytosis. Splenectomy because of spherocytosis has resulted in an increase in Ts cell number and diminution of Th/Ts ratio. Hereditary spherocytosis patients showed both diminished natural killer cell activity and AMLR proliferation. Splenectomy normalized the above parameters. The presented data demonstrated disturbances in T lymphocyte number and functions both before and after splenectomy in children with hereditary spherocytosis.
对13例遗传性球形红细胞增多症患者和21例脾切除术后患者（因遗传性球形红细胞增多症而进行手术）的淋巴细胞亚群及自体混合淋巴细胞反应（AMLR）进行了研究。已注意到遗传性球形红细胞增多症患儿的Th细胞及Th/Ts比值显著升高。因球形红细胞增多症进行的脾切除术导致Ts细胞数量增加及Th/Ts比值降低。遗传性球形红细胞增多症患者的自然杀伤细胞活性及AMLR增殖均降低。脾切除使上述参数恢复正常。所呈现的数据表明，遗传性球形红细胞增多症患儿在脾切除术前和术后T淋巴细胞数量及功能均存在紊乱。
