Meng Ran, Ji Xunming, Wang Xiaoying, Ding Yuchuan
Department of Neurology, Beijing Shijitan Hospital affiliated Capital Medical University, The Ninth Clinical Medical College of Peking University, Beijing, China; ; Department of Neurosurgery, Cerebral Vascular Diseases Research Institute (China-America Joint Institute of Neuroscience), Xuanwu Hospital, Capital Medical University, Key Lab of Neurodegenerative Diseases of Ministry of Education, Beijing, China; ; Deepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;
Department of Neurosurgery, Cerebral Vascular Diseases Research Institute (China-America Joint Institute of Neuroscience), Xuanwu Hospital, Capital Medical University, Key Lab of Neurodegenerative Diseases of Ministry of Education, Beijing, China;
Intractable Rare Dis Res. 2012 Feb;1(1):23-6. doi: 10.5582/irdr.2012.v1.1.23.
Cerebral venous sinus thrombosis (CVST) is an uncommon but life-threatening stroke subtype with extremely diverse clinical features, predisposing factors, brain imaging findings, and outcomes. Its predominant etiologies were known to be otomastoid, orbit, and central face cutaneous infections, pregnancy and complications associated with the postpartum period, and oral contraceptives. In recent years, however, infections have accounted for fewer cases while oral contraceptives, pregnancy and complications associated with the postpartum period, tumors, and coagulopathies have accounted for more cases of CVST. These conditions have become the predominant risk factors for CVST, but uncommon etiologies have also emerged. This review focuses on the new etiologies of CVST cases reported this year to broaden perspectives on the etiologies of CVST.
脑静脉窦血栓形成(CVST)是一种罕见但危及生命的卒中亚型,具有极其多样的临床特征、诱发因素、脑影像学表现及预后。其主要病因已知为耳乳突、眼眶及面部中央皮肤感染、妊娠及产后期相关并发症以及口服避孕药。然而近年来,感染导致的病例减少,而口服避孕药、妊娠及产后期相关并发症、肿瘤及凝血障碍导致的CVST病例增多。这些情况已成为CVST的主要危险因素,但也出现了一些罕见病因。本综述聚焦于今年报道的CVST病例的新病因,以拓宽对CVST病因的认识。