Hökl J, Filkuka J, Neumannová M, Sobotová D
Research Institute of Cardiovascular and Transplant Surgery, Brno.
Czech Med. 1989;12(4):189-92.
The response of T-helper and T-suppressor cells to various immunosuppressive regimens was studied in long surviving cadaveric renal allograft recipients. Eight patients were immunosuppressed with Azathioprine and corticosteroids, 12 recipients were treated with a combination of Cyclosporin A, corticosteroids and Azathioprine for 1 year. Both regimens decreased the Th/Ts ratio significantly as compared with healthy controls (p less than 0.05). No correlation between the Th/Ts ratio and the serum creatinine concentration was found. Likewise, the Th/Ts ratio did not correlate with Cyclosporin A blood levels.
在长期存活的尸体肾移植受者中研究了辅助性T细胞和抑制性T细胞对各种免疫抑制方案的反应。8例患者接受硫唑嘌呤和皮质类固醇免疫抑制治疗，12例受者接受环孢素A、皮质类固醇和硫唑嘌呤联合治疗1年。与健康对照组相比，两种方案均显著降低了Th/Ts比值（p<0.05）。未发现Th/Ts比值与血清肌酐浓度之间存在相关性。同样，Th/Ts比值与环孢素A血药浓度也无相关性。
