热疗和/或烟酰胺对C3H乳腺癌辐射反应的影响。

Effect of hyperthermia and/or nicotinamide on the radiation response of a C3H mammary carcinoma.

作者信息

Kjellén E, Pero R W, Nilsson P, Hill S A

机构信息

CRC Gray Laboratory, Mount Vernon Hospital, Northwood, Middlesex, U.K.

出版信息

Eur J Cancer Clin Oncol. 1989 Dec;25(12):1733-7. doi: 10.1016/0277-5379(89)90342-8.

DOI:10.1016/0277-5379(89)90342-8

PMID:2534381

Abstract

The effect of hyperthermia and/or nicotinamide (200 mg/kg of body weight) on the tumour growth delay induced by radiation was evaluated in a C3H mouse mammary adenocarcinoma. The study showed a radiosensitizing effect of hyperthermia and of nicotinamide but the combination of all three modalitites showed no increased tumor growth delay compared to hyperthermia and radiation alone. The tumour growth delay induced by hyperthermia was not modified by nicotinamide.

摘要

在C3H小鼠乳腺腺癌中评估了热疗和/或烟酰胺（200mg/kg体重）对辐射诱导的肿瘤生长延迟的影响。研究显示热疗和烟酰胺均有放射增敏作用，但与单独的热疗和放疗相比，三种治疗方式联合使用并未显示出肿瘤生长延迟增加。烟酰胺并未改变热疗诱导的肿瘤生长延迟。