Jonsson G G, Kjellén E, Pero R W
Radiother Oncol. 1984 Mar;1(4):349-53. doi: 10.1016/s0167-8140(84)80023-7.
Inhibitors of the chromosomal enzyme ADP-ribosyl transferase, like nicotinamide, have been shown to inhibit DNA strand rejoining and also to potentiate the lethality of DNA damaging agents in vitro. We have examined the radiosensitizing potential of nicotinamide in vivo by using transplanted C3H mouse mammary adenocarcinomas as our model system. Our data indicate a radiosensitizing effect for nicotinamide.
染色体酶ADP-核糖基转移酶的抑制剂，如烟酰胺，已被证明在体外可抑制DNA链的重新连接，还能增强DNA损伤剂的致死性。我们通过使用移植的C3H小鼠乳腺腺癌作为模型系统，研究了烟酰胺在体内的放射增敏潜力。我们的数据表明烟酰胺具有放射增敏作用。
