男性日常生活中的心钠素与肾小管钠处理

Atrial natriuretic peptides and tubular sodium handling during normal daily life in men.

作者信息

Cappuccio F P, Strazzullo P, Barba G, Iacone R, Buckley M G, Sugden A L, Miller M, Sagnella G A, MacGregor G A, Mancini M

机构信息

Department of Internal Medicine and Metabolic Diseases, 2nd Medical School, University of Naples, Italy.

出版信息

J Hypertens Suppl. 1989 Dec;7(6):S228-9. doi: 10.1097/00004872-198900076-00110.

DOI:10.1097/00004872-198900076-00110

PMID:2534404

Abstract

The relationship between segmental renal tubular sodium handling (using the renal clearance of ingested lithium as a marker of proximal tubular sodium handling) and circulating plasma levels of atrial natriuretic factor (ANF) was studied in a sample of 295 untreated men drawn from a male population at work under their usual living conditions. Plasma ANF was positively and significantly related to sodium excretion at the distal nephron, indicating that this hormone interacts with a distal renal tubular site to influence the control of sodium excretion in man.

摘要

在295名处于正常生活条件下工作的男性样本中，研究了节段性肾小管钠处理（使用摄入锂的肾脏清除率作为近端肾小管钠处理的标志物）与心房利钠因子（ANF）循环血浆水平之间的关系。血浆ANF与远端肾单位的钠排泄呈正相关且具有显著相关性，表明该激素与远端肾小管部位相互作用，以影响人体钠排泄的控制。