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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Freestone S, Jeffrey R F, Bonner C V, Lee M R

University Department of Clinical Pharmacology, Royal Infirmary, Edinburgh, U.K.

Clin Sci (Lond). 1990 Apr;78(4):371-5. doi: 10.1042/cs0780371.

alpha-Human atrial natriuretic peptide (7.5 pmol min-1 kg-1) was infused intravenously into eight healthy men after pretreatment with lithium carbonate (750 mg) or placebo. 2. Baseline sodium excretion was significantly increased after lithium, but the natriuresis during infusion of alpha-human atrial natriuretic peptide was attenuated. 3. Similar decreases in plasma renin activity with infusion of alpha-human atrial natriuretic peptide occurred on both days. 4. Administration of lithium may be associated with pharmacological effects and further work is required to validate the use of lithium clearance as a marker of proximal renal tubular sodium handling.

在八名健康男性预先服用碳酸锂（750毫克）或安慰剂后，静脉输注α-人心房利钠肽（7.5皮摩尔·分钟-1·千克-1）。2. 锂治疗后基线钠排泄显著增加，但输注α-人心房利钠肽期间的利钠作用减弱。3. 两天内输注α-人心房利钠肽时血浆肾素活性均有类似下降。4. 锂的给药可能与药理作用有关，需要进一步研究以验证将锂清除率作为近端肾小管钠处理标志物的用途。

Freestone S, Jeffrey R F, Bonner C V, Lee M R

University Department of Clinical Pharmacology, Royal Infirmary, Edinburgh, U.K.

Clin Sci (Lond). 1990 Apr;78(4):371-5. doi: 10.1042/cs0780371.

alpha-Human atrial natriuretic peptide (7.5 pmol min-1 kg-1) was infused intravenously into eight healthy men after pretreatment with lithium carbonate (750 mg) or placebo. 2. Baseline sodium excretion was significantly increased after lithium, but the natriuresis during infusion of alpha-human atrial natriuretic peptide was attenuated. 3. Similar decreases in plasma renin activity with infusion of alpha-human atrial natriuretic peptide occurred on both days. 4. Administration of lithium may be associated with pharmacological effects and further work is required to validate the use of lithium clearance as a marker of proximal renal tubular sodium handling.

在八名健康男性预先服用碳酸锂（750毫克）或安慰剂后，静脉输注α-人心房利钠肽（7.5皮摩尔·分钟-1·千克-1）。2. 锂治疗后基线钠排泄显著增加，但输注α-人心房利钠肽期间的利钠作用减弱。3. 两天内输注α-人心房利钠肽时血浆肾素活性均有类似下降。4. 锂的给药可能与药理作用有关，需要进一步研究以验证将锂清除率作为近端肾小管钠处理标志物的用途。