Department of Neurology, Oslo University Hospital, Norway/Institute of Clinical Medicine, University of Oslo, Norway
Department of Neurology, Oslo University Hospital, Norway.
Mult Scler. 2015 May;21(6):695-702. doi: 10.1177/1352458514554055. Epub 2014 Oct 24.
Multiple sclerosis (MS) prevalence is unevenly distributed worldwide. Immigration to Norway from countries with a lower MS prevalence is increasing. The aim of this study was to investigate MS prevalence in different immigrant populations in Norway and evaluate the effect of migrating from low- to high-risk regions of MS.
First- and second-generation immigrants from the largest immigrant populations were identified from the 2012 Norwegian prevalence study. Prevalence of MS in different ethnic groups was compared using the standardized prevalence ratio (SPR).
European and North-American immigrants had the highest prevalence of MS, whereas African and Asian immigrants had the lowest. The prevalence of first-generation Iranian immigrants was not significantly different from the total Norwegian population (SPR 0.70, 95% CI: 0.46-1.03). Second-generation immigrants from Pakistan (SPR 1.62, 95% CI: 0.88-2.76) had a strong increase in prevalence compared to the first generation (SPR 0.13, 95% CI: 0.05-0.28).
MS prevalence among immigrants in Norway in general reflects the uneven distribution worldwide. The sharp increase in prevalence in immigrants seen in one generation suggests strong environmental factors affecting the MS risk in Norway.
多发性硬化症（MS）的患病率在全球分布不均。从 MS 患病率较低的国家移民到挪威的人数正在增加。本研究旨在调查挪威不同移民人群中的 MS 患病率，并评估从 MS 低风险地区移民到高风险地区的影响。
从 2012 年挪威患病率研究中确定了最大移民群体的第一代和第二代移民。使用标准化患病率比（SPR）比较不同族裔群体的 MS 患病率。
欧洲和北美人种的移民 MS 患病率最高，而非洲和亚洲移民的患病率最低。第一代伊朗移民的 MS 患病率与挪威总人口无显著差异（SPR0.70，95%CI：0.46-1.03）。与第一代移民（SPR0.13，95%CI：0.05-0.28）相比，来自巴基斯坦的第二代移民（SPR1.62，95%CI：0.88-2.76）的患病率显著增加。
挪威移民中的 MS 患病率总体上反映了全球分布不均的情况。一代人中 MS 患病率的急剧增加表明，影响挪威 MS 风险的环境因素很强。
