Haghikia A, Linker R A
Neurologische Klinik, St. Josef-Hospital/Ruhr Universität Bochum, Gudrunstr. 56, 44971, Bochum, Deutschland.
Neurologische Klinik, Universitätsklinikum Erlangen, Schwabachanlage 6, 91054, Erlangen, Deutschland.
Nervenarzt. 2018 Apr;89(4):463-471. doi: 10.1007/s00115-018-0497-1.
Epidemiological data indicate a disproportional increase in the incidence of multiple sclerosis (MS) over the last decades, particularly in industrialized countries. Although this increase is also associated with altered diagnostic criteria and improved sensitivity of imaging procedures, current data suggest that particularly alterations in our way of life play an important role. In recent years the importance of the gut and intestinal microbiome for some neurological diseases and in particular for MS was recognized. Because nutritional habits have a substantial influence on the composition of the microbiome and our nutrition has changed considerably in the last decades, nutritional components can play an important role in the pathogenesis of MS. In this further education article we summarize the currently available evidence on the role of the gut and on the effects of dietary components on the microbiome in the pathogenesis of MS.
流行病学数据表明，在过去几十年中，多发性硬化症（MS）的发病率呈不成比例的增长，尤其是在工业化国家。尽管这种增长也与诊断标准的改变和成像程序敏感性的提高有关，但目前的数据表明，我们生活方式的改变尤其起着重要作用。近年来，肠道和肠道微生物群对某些神经系统疾病，特别是对MS的重要性得到了认可。由于饮食习惯对微生物群的组成有重大影响，并且在过去几十年中我们的营养发生了相当大的变化，营养成分可能在MS的发病机制中发挥重要作用。在这篇继续教育文章中，我们总结了目前关于肠道作用以及饮食成分对MS发病机制中微生物群影响的现有证据。
