Scieglinska Dorota, Krawczyk Zdzislaw
Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Wybrzeże Armii Krajowej 15, 44-101, Gliwice, Poland,
Cell Stress Chaperones. 2015 Mar;20(2):221-35. doi: 10.1007/s12192-014-0548-x. Epub 2014 Oct 25.
The HSPA2 gene is a poorly characterized member of the HSPA (HSP70) family. HSPA2 was originally described as testis-specific and expressed at the highest level in pachytene spermatocytes of rodents, the expression of which is not induced by heat shock. HSPA2 is crucial for male fertility. However, recent advances have shown that HSPA2 is expressed in various tumors and in certain types of somatic tissues. In this review, we summarize the current knowledge on the HSPA2 expression pattern, including information on transcriptional, translational, posttranslational, and epigenetic mechanisms which regulate HSPA2 expression. We also present and discuss the current views concerning the functions of the HSPA2 protein in spermatogenetic, somatic, and cancer cells. The knowledge of the properties of HSPA2, although limited, shows this protein as a unique member of the HSPA family. However, understanding whether this protein could become a relevant cancer biomarker or a therapeutically applicable target requires extensive further studies.
HSPA2基因是热休克蛋白70（HSPA）家族中一个特征尚不明确的成员。HSPA2最初被描述为睾丸特异性基因，在啮齿动物的粗线期精母细胞中表达水平最高，其表达不受热休克诱导。HSPA2对雄性生育至关重要。然而，最近的研究进展表明，HSPA2在各种肿瘤和某些类型的体细胞组织中也有表达。在本综述中，我们总结了目前关于HSPA2表达模式的知识，包括调节HSPA2表达的转录、翻译、翻译后和表观遗传机制的相关信息。我们还介绍并讨论了目前关于HSPA2蛋白在生精细胞、体细胞和癌细胞中功能的观点。尽管对HSPA2特性的了解有限，但这表明该蛋白是HSPA家族中的一个独特成员。然而，要确定该蛋白是否能成为相关的癌症生物标志物或治疗靶点，还需要进行大量的进一步研究。
