Zamparini Guillaume, Butin Géraldine, Fischer Marc-Olivier, Gérard Jean-Louis, Hanouz Jean-Luc, Fellahi Jean-Luc
Department of Anesthesiology and Critical Care Medicine, Pôle Réanimations Anesthésie SAMU, CHU de Caen, Avenue de la Côte de Nacre, 14000, Caen, France.
Faculty of Medicine EA4650, Caen University, 14000, Caen, France.
J Clin Monit Comput. 2015 Oct;29(5):555-9. doi: 10.1007/s10877-014-9631-1. Epub 2014 Oct 25.
Smokers are exposed to early endothelial dysfunction. This microcirculatory damage can be demonstrated by near-infrared spectroscopy (NIRS). The aim of this study was to compare microvascular reactivity by NIRS during a dynamic vascular occlusion test in healthy smokers and nonsmokers volunteers. Twenty healthy volunteers (10 men, 10 women), aged from 22 to 38 years old, were included after approval of the local Ethics Committee and divided into two groups: smokers (n = 10) and nonsmokers (n = 10). Tissue oxygen saturation (StO2) was measured at the level of each individual's calves during an ischemia and reperfusion test. In addition, during the ischemia phase, the slope of decline in StO2 was determined. Therefore, for each group, we were able to deduce the speed of desaturation (ΔStO2/ischemia time). The same was applied for resaturation rates during the reperfusion phase (ΔStO2/reperfusion time). StO2 values were comparable at all experimental steps between smokers and nonsmokers. During the vascular occlusion test, rates of desaturation were the same between smokers and nonsmokers [respectively 3.7%·min(-1) (range 2.5-12.6) and 3.7%·min(-1) (range 1.8-15.1); p = 0.50]. It was the same for the rate of resaturation [smokers 30.4%·min(-1) (range 14.2-51.6) and nonsmokers 30.5%·min(-1) (range 18.6-44.5); p = 0.82]. NIRS study of microvascular reactivity during a dynamic vascular occlusion test did not reveal any difference between smokers and nonsmokers. Therefore, NIRS could not be sensitive enough to highlight endothelial dysfunction in healthy subjects exposed to tobacco smoke.
吸烟者会出现早期内皮功能障碍。这种微循环损伤可通过近红外光谱（NIRS）检测出来。本研究的目的是比较健康吸烟者和非吸烟者志愿者在动态血管闭塞试验期间通过NIRS测得的微血管反应性。经当地伦理委员会批准，纳入了20名年龄在22至38岁之间的健康志愿者（10名男性，10名女性），并将其分为两组：吸烟者（n = 10）和非吸烟者（n = 10）。在缺血再灌注试验期间，在每个个体的小腿水平测量组织氧饱和度（StO2）。此外，在缺血阶段，测定StO2的下降斜率。因此，对于每组，我们能够推导出去饱和速度（ΔStO2/缺血时间）。再灌注阶段的再饱和率（ΔStO2/再灌注时间）也是如此。吸烟者和非吸烟者在所有实验步骤中的StO2值具有可比性。在血管闭塞试验期间，吸烟者和非吸烟者的去饱和率相同[分别为3.7%·min⁻¹（范围2.5 - 12.6）和3.7%·min⁻¹（范围1.8 - 15.1）；p = 0.50]。再饱和率也是如此[吸烟者30.4%·min⁻¹（范围14.2 - 51.6）和非吸烟者30.5%·min⁻¹（范围18.6 - 44.5）；p = 0.82]。动态血管闭塞试验期间微血管反应性的NIRS研究未发现吸烟者和非吸烟者之间存在任何差异。因此，NIRS可能不够敏感，无法突出暴露于烟草烟雾的健康受试者的内皮功能障碍。
