Siafaka Angeliki, Angelopoulos Epameinondas, Kritikos Konstantinos, Poriazi Magdalini, Basios Neofitos, Gerovasili Vasiliki, Andreou Antonios, Roussos Charis, Nanas Serafim
First Critical Care Department, Evangelismos Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Chest. 2007 May;131(5):1479-85. doi: 10.1378/chest.06-2017.
Cigarette smoking predisposes to vascular disease. Our study aimed to assess the acute effects of cigarette smoking on peripheral microcirculation using near-infrared spectroscopy (NIRS) and to compare microcirculatory function of smokers with that of nonsmokers.
We examined 65 healthy volunteers: 25 smokers (14 men and 11 women; age range, 20 to 27 years) and 40 nonsmokers (31 men and 9 women; age range, 19 to 38 years). Smokers had refrained from smoking for 2 h prior to the examination. Tissue O(2) saturation (Sto(2)), defined as the percentage of hemoglobin saturation in the microvasculature compartments, was measured with a probe placed on the thenar muscle. Sto(2) baseline values were recorded for 5 min. Subsequently, the brachial artery occlusion technique was applied to evaluate microcirculatory function before, during, and after smoking one cigarette.
Sto(2) before smoking was 85 +/- 6% (mean +/- SD), not differing significantly between men and women (84.4 +/- 6.6% vs 85.6 +/- 5.8%, respectively; p = 0.721). Sto(2) did not change significantly during smoking. O(2) consumption rate was significantly greater in women (33.4 +/- 6.7 Sto(2) U/min vs 25.7 +/- 7.1 Sto(2) U/min, p = 0.032) at baseline and throughout the smoking session. O(2) consumption rate was reduced during smoking (p < 0.001) and at 5 min after the smoking session. Smoking had a significant effect on vascular reactivity (p = 0.015), with no significant differences between genders. Five minutes after smoking, vascular reactivity had returned to approximately normal levels.
Smoking acutely affects microcirculatory function. NIRS is a noninvasive, operator-independent technique that can document these effects. It seems promising for the prospective evaluation of the effects of long-term exposure to cigarette smoke.
吸烟易引发血管疾病。我们的研究旨在使用近红外光谱法（NIRS）评估吸烟对周围微循环的急性影响，并比较吸烟者与非吸烟者的微循环功能。
我们检查了65名健康志愿者：25名吸烟者（14名男性和11名女性；年龄范围为20至27岁）和40名非吸烟者（31名男性和9名女性；年龄范围为19至38岁）。吸烟者在检查前2小时内未吸烟。用放置在大鱼际肌上的探头测量组织氧饱和度（Sto₂），即微血管腔室中血红蛋白饱和度的百分比。记录Sto₂基线值5分钟。随后，应用肱动脉闭塞技术评估吸一支烟之前、期间和之后的微循环功能。
吸烟前Sto₂为85±6%（平均值±标准差），男性和女性之间无显著差异（分别为84.4±6.6%和85.6±5.8%；p = 0.721）。吸烟期间Sto₂无显著变化。在基线和整个吸烟过程中，女性的氧消耗率显著更高（33.4±6.7 Sto₂ U/分钟对25.7±7.1 Sto₂ U/分钟，p = 0.032）。吸烟期间（p < 0.001）和吸烟后5分钟氧消耗率降低。吸烟对血管反应性有显著影响（p = 0.015），性别之间无显著差异。吸烟后5分钟，血管反应性已恢复到大致正常水平。
吸烟急性影响微循环功能。NIRS是一种非侵入性、不依赖操作者的技术，可记录这些影响。它对于前瞻性评估长期接触香烟烟雾的影响似乎很有前景。
